AI Article Synopsis
- Hyperosmotic stress from reduced tear production is a major contributor to dry eye disease, prompting research into potential preventive treatments.
- Oral administration of an extract (AB_SH) and its component fucoidan was tested in rats and human corneal cells, showing promising results in preventing apoptosis (cell death) and improving tear production.
- The findings suggest that both AB_SH and fucoidan can help alleviate symptoms of dry eye disease by protecting ocular tissues from damage.
Article Abstract
Hyperosmotic stress caused by tear hyposection is a leading cause of dry eye disease. We investigated the prevention of dry eye disease in corneal epithelial cells and in rats that were induced to develop dry eye disease via unilateral excision of their exorbital lacrimal gland using extract (AB_SH) and its bioactive component fucoidan. Oral administration of AB_SH (250 mg/kg and 500 mg/kg) and fucoidan (100 mg/kg) was conducted for 7 days. In order to measure tear secretion, phenol red thread tear tests were performed along with corneal irregularity measurements. The apoptotic injury in the cornea and the lacrimal gland was evaluated using TUNEL staining. AB_SH and fucoidan were shown to suppress apoptosis and the expression of apoptosis-related proteins in human corneal epithelial cells under hyperosmotic conditions. Oral administration of AB_SH and fucoidan attenuated tear hyposecretion and corneal irregularity in the lacrimal gland-excised rats. In addition, AB_SH and fucoidan also reduced apoptosis in the cornea and lacrimal gland. This study suggests that extract and fucoidan can effectively ameliorate dry eye disease by suppressing the apoptosis of ocular tissues.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10453645 | PMC |
| http://dx.doi.org/10.3390/cimb45080415 | DOI Listing |
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