Here we report a strategy for the facile assembly of fused 3-trifluoromethyl-1,2,4-triazoles, which are difficult to synthesize using traditional strategies, in 50-96% yields through a triethylamine-promoted intermolecular [3 + 2] cycloaddition pathway. This protocol features high efficiency, good functional group tolerance, mild conditions, and easy operation. Furthermore, a gram-scale reaction and product derivatizations were carried out smoothly to illustrate the practicability of this method.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1039/d3ob01133j | DOI Listing |
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!