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Type B Lactic Acidosis in a Patient with Mantle Cell Lymphoma. | LitMetric

AI Article Synopsis

  • - Type B lactic acidosis is a rare medical emergency caused by excess acid production, predominantly observed in patients with hematologic malignancies like lymphoma, not due to organ issues like hypoperfusion.* - This condition is linked to the "Warburg effect," where cancer cells alter their metabolism to produce more lactic acid, causing a poor prognosis if the underlying cancer is not treated.* - A case study of a 66-year-old man with type B lactic acidosis due to mantle cell lymphoma highlights the importance of early diagnosis and treatment, which included bicarbonate for acid correction and chemotherapy for the cancer, resulting in a successful outcome.*

Article Abstract

Type B lactic acidosis is an uncommon medical emergency in which acid production overwhelms hepatic clearance. This specific etiology of lactic acidosis occurs without organ hypoperfusion and has been most commonly described in patients with hematologic malignancies but also in patients with solid tumors. The mechanism by which cancer cells switch their glucose metabolism toward increasingly anaerobic glycolytic phenotypes has been described as the "Warburg effect." Without treating the underlying malignancy, the prognosis for patients diagnosed with malignancy-related type B lactic acidosis is extremely poor. Here, we present a case of a 66-year-old male who was diagnosed with type B lactic acidosis secondary to mantle cell lymphoma. Bicarbonate drip was started to correct the lactic acidosis. The patient was also immediately treated with rituximab chemotherapy combined with rasburicase to avoid the hyperuricemia associated with tumor lysis syndrome. He responded to the early treatment and was discharged with normal renal function. Type B lactic acidosis secondary to hematologic malignancy is important to recognize. In order to successfully treat this syndrome, early diagnosis and simultaneous treatment of the imbalance of lactic acid levels and the underlying malignancy are necessary.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10447056PMC
http://dx.doi.org/10.1155/2023/7021123DOI Listing

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