Pharmacokinetics and bioavailability of meloxicam in Pekin ducks following intravenous, intramuscular and oral administration.

Vet Anaesth Analg

Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Selcuk, Konya, Turkiye.

Published: November 2023

Objective: To determine the pharmacokinetics and bioavailability of meloxicam following intravenous (IV), intramuscular (IM), and oral administrations at a dose of 1.0 mg kg in Pekin ducks.

Study Design: Randomized experimental trial.

Animals: A total of 18 clinically healthy male Pekin ducks.

Methods: Pekin ducks were randomly assigned to three groups of six ducks: IV, IM and oral. Meloxicam (1.0 mg kg) was administered to each Pekin duck. A non-compartmental analysis was used to evaluate pharmacokinetic parameters.

Results: No local or systemic adverse effects were observed in any bird. Meloxicam was detected in the plasma up to 120 hours following IV, IM or oral administration. The elimination half-life of the IV route was slightly shorter than that of the IM and oral routes (p < 0.05). Following IV administration, volume of distribution at steady state and total clearance were 133.17 mL kg and 6.68 mL kg hour, respectively. The mean absorption time was 2.29 hours for IM and 1.13 hours for oral route. There were significant differences between IM and oral administration for the peak plasma concentration (C), time to reach C and bioavailability (p < 0.05).

Conclusions And Clinical Relevance: Meloxicam showed long elimination half-life and high bioavailability following IM and oral administration. Meloxicam in Pekin ducks provided the effective therapeutic concentration indicated in other species for up to 48 hours. However, there is a need to determine the clinical efficacy of meloxicam in Pekin ducks.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.vaa.2023.07.007DOI Listing

Publication Analysis

Top Keywords

pekin ducks
16
oral administration
16
meloxicam pekin
12
pharmacokinetics bioavailability
8
bioavailability meloxicam
8
intravenous intramuscular
8
oral
8
intramuscular oral
8
hours oral
8
elimination half-life
8

Similar Publications

Developmental changes of skin quality from breast, back, and thigh of Pekin ducks from 1 to 6 weeks of age.

Poult Sci

January 2025

State Key Laboratory of Livestock and Poultry Breeding, Guangdong Provincial Key Laboratory of Animal Nutrition and Regulation, College of Animal Science, South China Agricultural University, Guangzhou 510000, PR China. Electronic address:

Good skin quality not only improved carcass quality but also increased consumer demand for fresh poultry meat. This study aimed to investigate the developmental changes in skin growth and quality of Pekin ducks during 1-6 weeks of age. The skin samples were collected from the breast, back, and thigh tissues of six male ducks at the end of each week.

View Article and Find Full Text PDF

Genomic variation responding to artificial selection on different lines of Pekin duck.

Poult Sci

January 2025

Department of Animal Genetics and Breeding, National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural University, Yuanmingyuan West Road 2#, Beijing 100193, China. Electronic address:

Understanding the genomic variation in Pekin duck under artificial selection is important for improving the utilization of duck genetic resources. Here, the genomic changes in Pekin duck were analyzed by using the genome resequencing data from 96 individual samples, including 2 conservation populations and 4 breeding populations with different breeding backgrounds. The population structure, runs of homozygosity (ROH), effective population number (Ne), and other genetic parameters were analyzed.

View Article and Find Full Text PDF

A high-quality assembly revealing the PMEL gene for the unique plumage phenotype in Liancheng ducks.

Gigascience

January 2025

State Key Laboratory of Animal Biotech Breeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China.

Background: Plumage coloration is a distinctive trait in ducks, and the Liancheng duck, characterized by its white plumage and black beak and webbed feet, serves as an excellent subject for such studies. However, academic comprehension of the genetic mechanisms underlying duck plumage coloration remains limited. To this end, the Liancheng duck genome (GCA_039998735.

View Article and Find Full Text PDF

Identification of Candidate Genes for Sebum Deposition in Pekin Ducks Using Genome-Wide Association Studies.

Genes (Basel)

November 2024

Emergency Department, Shenzhen New Frontier United Family Healthcare, Shenzhen 518038, China.

Background: Sebum deposition is a vital trait influencing meat quality and production efficiency in Pekin ducks. Providing insights into the genetic basis of fat deposition could help improve breeding strategies aimed at producing high-quality meat ducks. This study aimed to identify the genetic mechanisms and lipid metabolism pathways regulating subcutaneous and intramuscular fat deposition in two Pekin duck strains: Nankou No.

View Article and Find Full Text PDF

We tested Pekin ducks with playbacks of 5 different vocalizations plus a no noise and white noise stimulus as our controls (N = 15 ducks/sex/treatment). The "AM long" call is a common vocalization made by both sexes. "Honk" is also produced by both sexes and is thought to be an alarm or distress call.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!