The severity of vehicle-pedestrian crashes has prompted authorities worldwide to concentrate on improving pedestrian safety. The situation has only become more urgent with the approach of automated driving scenarios. The Responsibility-Sensitive Safety (RSS) model, introduced by Mobileye®, is a rigorous mathematical model developed to facilitate the safe operation of automated vehicles. The RSS model has been calibrated for several vehicle conflict scenarios; however, it has not yet been tested for pedestrian safety. Therefore, this study calibrates and evaluates the RSS model for pedestrian safety using data from the Shanghai Naturalistic Driving Study. Nearly 400 vehicle-pedestrian conflicts were extracted from 8,000 trips by the threshold and manual check method, and then divided into 16 basic scenarios in three categories. Because crossing conflicts were the most serious and frequent, they were reproduced in MATLAB's Simulink with each vehicle replaced with a virtual automated vehicle loaded with the RSS controller module. With the objectives of maximizing safety and minimizing conservativeness, the non-dominated sorting genetic algorithm II was applied to calibrate the RSS model for vehicle-pedestrian conflicts. The safety performance of the RSS model was then compared with that of the commonly used active safety function, autonomous emergency braking (AEB), and with human driving. Findings verified that the RSS model was safer in vehicle-pedestrian conflicts than both the AEB model and human driving. Its performance also yielded the best test results in producing smooth and stable driving. This study provides a reliable reference for the safe control of automated vehicles with respect to pedestrians.
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http://dx.doi.org/10.1016/j.aap.2023.107265 | DOI Listing |
PLoS Genet
January 2025
Center for Human Genetics, Clemson University, Greenwood, South Carolina, United States of America.
Polygenic prediction of complex trait phenotypes has become important in human genetics, especially in the context of precision medicine. Recently, mr.mash, a flexible and computationally efficient method that models multiple phenotypes jointly and leverages sharing of effects across such phenotypes to improve prediction accuracy, was introduced.
View Article and Find Full Text PDFClin Transl Med
January 2025
Frazer Institute, Faculty of Medicine, The University of Queensland, Woolloongabba, Queensland, Australia.
Background: Paediatric sarcomas, including rhabdomyosarcoma, Ewing sarcoma and osteosarcoma, represent a group of malignancies that significantly contribute to cancer-related morbidity and mortality in children and young adults. These cancers share common challenges, including high rates of metastasis, recurrence or treatment resistance, leading to a 5-year survival rate of approximately 20% for patients with advanced disease stages. Despite the critical need, therapeutic advancements have been limited over the past three decades.
View Article and Find Full Text PDFClin Teach
February 2025
Department of Pediatric Cardiology, University Hospital Bonn, Bonn, Germany.
Introduction: In recent years, podcasts have been increasingly deployed in medical education. However, studies often fail to evaluate the learning outcomes from these podcasts effectively. The aim of this study was to determine whether the active production of podcasts enhances students' knowledge compared to the passive consumption of student-produced podcasts, as it increases the engagement with the learning content through active learning.
View Article and Find Full Text PDFLangmuir
January 2025
Key Laboratory of Insitu Property improving Mining of Ministry of Education, Taiyuan University of Technology, No,18 Xinkuangyuan Road, Wanbailin District, Taiyuan, Shanxi 030024, P. R. China.
In terms of the phenomenon of nonuniformity adsorption energy between methane and a natural heterogeneous coal surface, a heterogeneous potential well model is established in this study based on adsorption science and molecular dynamics theories. This model describes the methane adsorption positions in coal pores as a three-dimensional space composed of adsorption equipotential surfaces with varying depths of potential well, which emphasizes the heterogeneous distribution of methane adsorption potential well depths in coal and accurately describes the spatial distribution and energy states of methane molecules during methane adsorption and desorption in naturally heterogeneous coal. By taking the residual sum of squares (RSS) and Pearson correlation coefficient as indicators, the fitting accuracies of the Langmuir model and the heterogeneous potential well model for isothermal adsorption and desorption curves are compared so that the superiority of the heterogeneous potential well model in describing the adsorption and desorption of methane in natural coal is confirmed.
View Article and Find Full Text PDFIn unsupervised transfer learning for medical image segmentation, where existing algorithms face the challenge of error propagation due to inaccessible source domain data. In response to this scenario, source-free domain transfer algorithm with reduced style sensitivity (SFDT-RSS) is designed. SFDT-RSS initially pre-trains the source domain model by using the generalization strategy and subsequently adapts the pre-trained model to target domain without accessing source data.
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