Background: The leaves of "Khat" (Catha edulis), an indigenous shrub of Yemen and Arabian Peninsula are habitually chewed by the inhabitants for psychostimulant properties.
Objective: To describe a unique task specific Oro-mandibular dystonia (OMD) in Yemenese men, with a temporal association with chewing "Khat".
Methods: Multicentric, retrospective analysis (2009-2020) of patients with OMD associated with "Khat" chewing, evaluating clinical features and response to Onabotulinum toxin A.
Results: 35 Yemenese men with a negative family history, normal neuroimaging mean age of 44.31(±3.21) years and prolonged (20.31 ± 3.27 years) history of chewing Khat, around 5.16(±0.80) hours/day presented with OMD-20 jaw opening, 13 jaw closing and 2 mixed affecting chewing (n = 6), speech (n = 3), or both (n = 26). Additional lingual dystonia was seen in five.
Conclusions: Chewing of khat is a repetitive task involving the jaw musculature and may be one of the causative factors of this task specific OMD. Recognition can prevent disability in these regions.
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http://dx.doi.org/10.1016/j.parkreldis.2023.105806 | DOI Listing |
IBRO Neurosci Rep
June 2025
Department of Human Anatomy and Medical Physiology, Faculty of Health Sciences, University of Nairobi, P.O. Box 30197- 00100, Nairobi, Kenya.
Khat ( Forsk), the natural source of cathinone and other psychoactive agents, is chewed by millions of persons in eastern Africa and the Arabian Peninsula for its psychostimulant effect. Using the conditioned place preference paradigm, this study tested fresh khat extract for place preference induction, extinction, and reinstatement. Female mice treated with 100 and 250 mg/kg of khat extract showed conditioned place preference, which was extinguished following a 16-day khat-free period.
View Article and Find Full Text PDFJ Family Med Prim Care
November 2024
Abu Arish Chest Hospital, Jazan, Saudi Arabia.
Introduction: Oral cancer has emerged as a significant public health issue, with 90% of instances because of avoidable causes. Smokeless tobacco usage is thought to be a substantial source of cytological alterations in the oral mucosa, and snuff (Shamma) is often used in Saudi Arabia. In this study, we investigated community awareness of Shamma as a cause of oral cancer in the Jazan region's general population.
View Article and Find Full Text PDFInt J Gen Med
November 2024
Department of Neurology, Mogadishu Somali - Turkey Recep Tayyip Erdoğan Training and Research Hospital, Mogadishu, Somalia.
Objective: The plant known as , commonly referred to as Khat, holds significant cultural significance within the populations of East Africa and Southwestern Arabia. The objective of this study is to ascertain and assess the association between the act of chewing khat and the incidence of acute stroke.
Materials And Methods: The present study was carried out in a prospective observational manner at the Mogadishu-Somalia Turkish Training and Research Hospital.
BMC Pregnancy Childbirth
November 2024
School of Public Health, College of Medicine and Health Sciences, Wolaita Sodo University, Sodo Town, Ethiopia.
Background: The use of khat, alcohol, and cigarettes during pregnancy is a serious public health problem associated with harmful outcomes for the fetus and the mother's health. Studies that investigated khat, alcohol, and cigarettes usage during pregnancy yielded varied and contradictory results. This study used a systematic review and meta-analysis to estimate the pooled prevalence and associated factors of khat, alcohol, and cigarettes use among pregnant women in Africa.
View Article and Find Full Text PDFPLoS One
November 2024
Addis Ababa Institute of Technology-Addis Ababa University, School of Mechanical and Industrial Engineering, Addis Ababa, Ethiopia.
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