Intracoronary thrombolytic infusions were used in 10 patients with unstable angina and high risk of myocardial infarction (MI). Streptokinase (500,000 units per hour) was used in 9 patients, and urokinase, in one. Vascular recanalization was achieved in 4 cases where angiography showed coronary arterial occlusion by a thrombus. Myocardial infarction developed in 8 patients (large-focal in 6 and small-focal in 2) within 1 to 16 days after the thrombolytic infusion. Therefore, short-term local thrombolytic infusion fails to prevent myocardial infarction in patients with unstable angina.
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