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Therapeutic Efficacy of the Inositol D-Pinitol as a Multi-Faceted Disease Modifier in the 5×FAD Humanized Mouse Model of Alzheimer's Amyloidosis.
Nutrients
December 2024
Grupo de Neuropsicofarmacología, Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, Unidades Clínicas de Neurología y Salud Mental, 29010 Málaga, Spain.
Background/objectives: Alzheimer's disease (AD), a leading cause of dementia, lacks effective long-term treatments. Current therapies offer temporary relief or fail to halt its progression and are often inaccessible due to cost. AD involves multiple pathological processes, including amyloid beta (Aβ) deposition, insulin resistance, tau protein hyperphosphorylation, and systemic inflammation accelerated by gut microbiota dysbiosis originating from a leaky gut.
View Article and Find Full Text PDFThree Surgical Cases of Cecal Volvulus.
Cureus
October 2024
Department of Coloproctological Surgery, Juntendo University, Tokyo, JPN.
Cecal volvulus (CV) is a relatively rare disease; however, it often requires emergency surgery due to the low success rate of endoscopic treatment, in contrast to sigmoid volvulus. The mechanism of CV involves a mobile cecum at the base, triggered by factors such as constipation, high-fiber diets, laxative use, history of laparotomy or laparoscopic surgery, pregnancy, and prior colonoscopy, which twists the ileocecal region. Although CV is a benign disease, it can be fatal if treatment is delayed, so it is crucial to understand the pathophysiology and treatment.
View Article and Find Full Text PDFSecondary Amyloidosis Treated with Tocilizumab as a Complication of Temporal Arteritis.
Eur J Case Rep Intern Med
October 2024
Faculty of Medicine, Damascus University, Damascus, Syrian Arab Republic.
Background: Temporal arteritis is a large-vessel vasculitis mostly seen in the elderly. Amyloidosis may be secondary to a chronic inflammation of body organs. Here, we present the second case report of temporal arteritis complicated by amyloidosis that was successfully treated by tocilizumab.
View Article and Find Full Text PDFSubclinical amyloid deposition in inflammatory bowel diseases: A two hospital study.
Pathol Res Pract
December 2024
Department of Surgery, Dokkyo Medical University, Mibu, Tochigi, Japan.
Inflammatory bowel disease (IBD), which includes Crohn's disease (CD) and ulcerative colitis (UC), predominantly affects young patients and leads to intestinal complications. Amyloidosis, which involves abnormal protein deposition, is a serious complication of IBD, with a low incidence. Early detection of subclinical amyloid deposits is crucial for preventing fatal outcomes; however, routine investigations are lacking.
View Article and Find Full Text PDFMultiple endocrine neoplasia type 2 (MEN2) is the collective term for two distinct types of autosomal dominantly inherited neuroendocrine neoplasm syndromes: MEN2A and MEN2B (or MEN3). MEN2 is characterised by medullary thyroid cancer (MTC) (99%) and phaeochromocytoma (50%) and also other conditions according to specific genotype. MEN2A also includes a 25% risk of developing parathyroid hyperplasia and is now recognised as four separate syndromes: classic MEN2A, MEN2A with cutaneous lichen amyloidosis, MEN2A with Hirschsprung's disease and familial MTC.
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