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Interferon gamma release assay has potential in the prediction of chronic graft-versus-host disease in recipients of myeloablative allogeneic hematopoietic stem cell transplantation with post-transplantation cyclophosphamide-based graft-versus-host disease prophylaxis.
Transpl Immunol
December 2024
Department of Immunology, Institute of Hematology and Blood Transfusion, Prague, Czech Republic. Electronic address:
Background: The rate of immune reconstitution after allogeneic hematopoietic stem cell transplantation (allo-HSCT) plays the principal role in the development of serious post-transplant complications. However, the post-transplantation course has a significant impact on shaping the immune system of the recipient, per se, thus representing risk factors for subsequent unfavorable outcomes. The predictive power of an interferon gamma (IFNγ) release assay (IGRA) on graft-versus-host disease (GVHD) or hematological relapse in recipients of allo-HSCT treated with post-transplantation cyclophosphamide and the impact of these complications on the restoration of cellular immune responsiveness was evaluated.
View Article and Find Full Text PDFA novel conditioning regimen with pre-transplantation immunosuppression reduces the complication rates in hematopoietic stem cell transplantation in transfusion-dependent β-thalassemia.
Stem Cell Res Ther
December 2024
Department of Pediatrics, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, No.107, West Yan Jiang Road, Guangzhou, 510120, Guangdong, China.
Background: Allo-HSCT is a curative therapy for patients with transfusion-dependent thalassemia (TDT). The high incidence of transplant-related complications is becoming an obstacle to safe and effective unrelated donor (URD) transplantation.
Methods: In this retrospective study, we reported the survival outcomes and complications of transplantation in thalassemia patients using a novel regimen consisting of pre-transplantation immunosuppression (PTIS) and modified myeloablative conditioning based on intravenous busulfan, cyclophosphamide, fludarabine, and rabbit anti-human thymocyte immunoglobulin.
Predictive factors for engraftment kinetics of autologous hematopoietic stem cells in children.
Hematol Transfus Cell Ther
December 2024
Mother and Child Health Care Institute of Serbia "Dr. Vukan Čupić", Belgrade, Serbia; Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
Background: Engraftment after hematopoietic stem cell transplantation is the recovery rate of neutrophils and platelets. This study aimed to test the impact of the patient's general characteristics, pre-transplantation factors, and quality parameters of hematopietic stem cell products on hematopietic recovery and to define predictive factors for engraftment in children.
Methods: This retrospective study included 52 patients aged from 1 to 18 years old treated with autologous transplantation at the Mother and Child Health Care Institute of Serbia "Dr.
Impact of induction agents and maintenance immunosuppression on torque teno virus loads and year-one complications after kidney transplantation.
Front Immunol
November 2024
Department of Nephrology, University Hospital Heidelberg, Heidelberg, Germany.
Article Synopsis
- Torque teno virus load (TTVL) is being studied as a way to measure immune health in kidney transplant patients, particularly how different medications affect TTVL levels.
- In a study of 134 patients, TTVL levels peaked at 90 days post-transplant and were significantly higher in those who received anti-thymocyte globulin (ATG) compared to interleukin-2 receptor antagonists (IL2-RA).
- Higher TTVL levels may indicate a greater risk of infections for patients, though this trend wasn't statistically significant, suggesting that monitoring TTVL could help manage immunosuppressive therapy post-transplant.
Importance of measurable residual disease in the outcome of adults with acute lymphoblastic leukemia after allogeneic stem cell transplantation: Long follow-up analysis from a single transplant center.
Med Clin (Barc)
November 2024
Hematology Department, Hospital Universitario de La Princesa, Madrid, Spain; Facultad de Medicina, Universidad Autónoma de Madrid, Madrid, Spain.
Introduction: In this retrospective study, with prolonged follow-up, we analyze the outcomes of allogeneic hematopoietic stem cell transplantation (allo-HSCT) in adult acute lymphoblastic leukemia (ALL) and the impact of pre-transplantation measurable residual disease (pre-HSCT MRD).
Methods: Detection of MRD was performed by multiparametric flow cytometry (MFC) for Philadelphia chromosome-negative ALL (Ph-neg ALL) and by classic genetic tests for Ph-pos ALL.
Results: Among 46 patients in first complete remission (CR1) who had available MRD data, 1- and 3-year cumulative incidences of relapse (CIR) for patients with positive and negative MRD were 47.
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