Purpose: To investigate whether the volume of white matter hyperintensity (WMH) extracted from FLAIR images changes when the imaging parameters of the original images are changed.
Methods: Seven healthy volunteers were imaged by changing the imaging parameter ETL of FLAIR images, and WMHs were extracted and their volumes were calculated by the automatic extraction software. The results were statistically analyzed to examine the relationship (Experiment 1). Simulated images with different SNRs were created by adding white noise to four examples of healthy volunteer images. The SNR of the simulated images simulated the SNR of the measured images of different ETLs. The WMH was extracted from the simulated images and its volume was calculated using the automatic extraction software (Experiment 2).
Results: Experiment 1 showed that there was no significant difference between FLAIR imaging parameters and WMH volume in automatic white matter signal analysis, except for some conditions. Experiment 2 showed that as the SNR of the original image decreased, the volume of high white matter signal extracted decreased.
Conclusion: In automatic white matter signal analysis, WMH was shown to be small when the ETL of the FLAIR sequence was larger than normal and/or the SNR of the image was low.
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