AI Article Synopsis
- Fetal alcohol spectrum disorders (FASD) refer to the range of neurological issues caused by prenatal alcohol exposure (PAE), impacting brain development.
- PAE leads to various brain malformations and disruptions, and recent research suggests that neuroinflammation may contribute significantly to these neurotoxic effects.
- The text emphasizes the need for more attention on neuroinflammation in diagnosing and treating FASD, discussing potential therapeutic interventions involving anti-inflammatory drugs and nutraceuticals.
Article Abstract
Fetal alcohol spectrum disorders (FASD) is an umbrella term to describe the neurological effects of prenatal alcohol exposure (PAE). It has been extensively characterized that PAE causes cell proliferation disruption, heterotopias, and malformations in various brain regions and there is increasing evidence that neuroinflammation is responsible for some of these neurotoxic effects. Despite evidence of its importance, neuroinflammation is not usually considered at diagnosis or treatment for FASD. Here, we discuss the literature regarding anti- inflammatory drugs and nutraceuticals, which hold promise for future therapeutical interventions in these disorders.
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| http://dx.doi.org/10.1016/j.bbadis.2023.166854 | DOI Listing |
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