Background And Objective: Image-guided clinical diagnosis can be achieved by automatically and accurately segmenting prostate and prostatic cancer in male pelvic magnetic resonance imaging (MRI) images. For accurate tumor removal, the location, number, and size of prostate cancer are crucial, especially in surgical patients. The morphological differences between the prostate and tumor regions are small, the size of the tumor is uncertain, the boundary between the tumor and surrounding tissue is blurred, and the classification that separates the normal region from the tumor is uneven. Therefore, segmenting prostate and tumor on MRI images is challenging.
Methods: This study offers a new prostate and prostatic cancer segmentation network based on double branch attention driven multi-scale learning for MRI. To begin, the dual branch structure provides two input images with different scales for feature coding, as well as a multi-scale attention module that collects details from different scales. The features of the double branch structure are then entered into the built feature fusion module to get more complete context information. Finally, to give a more precise learning representation, each stage is built using a deep supervision mechanism.
Results: The results of our proposed network's prostate and tumor segmentation on a variety of male pelvic MRI data sets show that it outperforms existing techniques. For prostate and prostatic cancer MRI segmentation, the dice similarity coefficient (DSC) values were 91.65% and 84.39%, respectively.
Conclusions: Our method maintains high correlation and consistency between automatic segmentation results and expert manual segmentation results. Accurate automatic segmentation of prostate and prostate cancer has important clinical significance.
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http://dx.doi.org/10.1016/j.compbiomed.2023.107374 | DOI Listing |
West Afr J Med
September 2024
Urology Department, Dorset County Hospital, Dorchester, UK.
Introduction: Prostate cancer (PCa) is the commonest urologic cancer worldwide and the leading cause of male cancer deaths in Nigeria. In Nigeria, orchidectomy remains the primary androgen deprivation therapy. Dihydrotestosterone (DHT) is the active prostatic androgen, but its relationship with PCa severity has not been extensively studied in Africa.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Radiology, The Yancheng School of Clinical Medicine of Nanjing Medical University, Yancheng Third People's Hospital, Yancheng, China.
We intended to investigate the potential of several transitional zone (TZ) volume-related variables for the detection of clinically significant prostate cancer (csPCa) among lesions scored as Prostate Imaging Reporting and Data System (PI-RADS) category 3. Between September 2018 and August 2023, patients who underwent mpMRI examination and scored as PI-RADS 3 were queried from our institution. The diagnostic performances of prostate-specific antigen density (PSAD), TZ-adjusted PSAD (TZPSAD), and TZ-ratio (TZ volume/whole gland prostate volume) were analyzed.
View Article and Find Full Text PDFStem Cell Res
January 2025
Department of Urology, Jinshan Hospital of Fudan University, Shanghai, China. Electronic address:
Prostate cancer (PCa) is the most common malignant tumor of the male reproductive system. In this study, we establish an induced pluripotent stem cell (iPSC) line from a male diagnosed with PC. of This iPSCs line was generated from the peripheral blood mononuclear cells (PBMCs) using a non-integrated Sendai virus.
View Article and Find Full Text PDFTransl Oncol
January 2025
Department of Urology, Cedars Sinai Medical Center, 8635 W. Third St, 1070, Los Angeles, CA 90048, United States. Electronic address:
Treatment options for localized prostate cancer have been expanded by FDA-approval of High-Intensity Focused Ultrasound (HIFU). Prostate cancer typically has few tumor-infiltrating lymphocytes, which are crucial for antitumor immunity. This study investigated the use of HIFU to increase lymphocyte infiltration into the tumor and enhance antitumor immunity.
View Article and Find Full Text PDFEur J Nucl Med Mol Imaging
January 2025
Department of Nuclear Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Purpose: This study aimed to identify if a subset of men can safely avoid or delay prostate biopsy based on negative results of prostate-specific membrane antigen positron emission tomography (PSMA-PET).
Materials And Methods: Among 341 consecutive cases in a prospective biopsy cohort (NCT05073653), 111 treatment-naïve men with negative PSMA-PET (PRIMARY-score 1/2) were included. All participants underwent PSMA-PET and histopathological examinations.
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