AI Article Synopsis
- The study examined cases of Guillain-Barré syndrome (GBS) following COVID-19 vaccination compared to non-vaccinated GBS cases in Buenos Aires, involving 91 patients treated from March 2020 to March 2022.
- Patients who had been vaccinated showed a higher incidence of cranial nerve involvement and bilateral facial paralysis, but overall clinical severity scores and other neurophysiological characteristics were similar between the two groups.
- The findings suggest a need for further research to clarify any potential link between COVID-19 vaccination and GBS, particularly through ongoing vaccine safety monitoring and epidemiological studies.
Article Abstract
In the context of the global vaccination campaign against COVID-19, several cases of postvaccinal Guillain-Barré syndrome (GBS) were reported. Whether a causal relationship exists between these events has yet to be established. We investigated the clinical and electromyographic characteristics of patients who developed GBS after COVID-19 vaccination and compare these with findings in patients with GBS, without a history of recent vaccination. We included 91 cases between March 2020 and March 2022, treated at 10 referral hospitals of Buenos Aires, Argentina. Of these, 46 had received vaccination against COVID-19 within the previous month. Although Medical Research Council sum-scores were similar in both groups (median 52 vs. 50; P = 0.4), cranial nerve involvement was significantly more frequent in the postvaccination group (59% vs. 38%; P = 0.02), as was bilateral facial paralysis (57% vs. 24%; P = 0.002). No differences were found in clinical or neurophysiological phenotypes, although 17 subjects presented the variant of bilateral facial palsy with paresthesias (11 vs. 6; P = 0.1); nor were significant differences observed in length of hospital stay or mortality rates. Future vaccine safety monitoring and epidemiology studies are essential to demonstrate any potential causal relationship between these events.
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| http://dx.doi.org/10.1097/CND.0000000000000437 | DOI Listing |
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