-amylase inhibition and studies of novel naphtho[2,3-]imidazole-4,9-dione linked -acyl hydrazones.

To enrich the pool of -amylase inhibitors to manage Type 2 diabetes. Synthesis, conformational study, -amylase inhibitory action and various studies of novel -(arylbenzylidene)-2-(4,9-dioxo-4,9-dihydro-1-naphtho[2,3-]imidazol-1-yl)acetohydrazides carried out. Compound demonstrated the highest activity (IC = 0.0437 μmol mL) among the tested compounds. Structure-activity relationship study suggested that variable substitution at the aryl ring has a pivotal role in determining the inhibitory action of tested compounds. Docking simulations of the most active compound () confirmed its interaction potential with active site residues of -amylase. The root-mean-square deviation fluctuations substantiated the stability of protein-ligand complex. Absorption, distribution, metabolism and excretion prediction revealed optimal values for absorption, distribution, metabolism and excretion parameters. The developed molecules could be beneficial for the development of novel -amylase inhibitors to treat Type 2 diabetes.