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| http://dx.doi.org/10.1007/s10488-023-01291-w | DOI Listing |
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Society for Immunotherapy of Cancer: updates and best practices for multiplex immunohistochemistry (IHC) and immunofluorescence (IF) image analysis and data sharing.
J Immunother Cancer
January 2025
Providence Portland Medical Center, Portland, Oregon, USA.
Objectives: Multiplex immunohistochemistry and immunofluorescence (mIHC/IF) are emerging technologies that can be used to help define complex immunophenotypes in tissue, quantify immune cell subsets, and assess the spatial arrangement of marker expression. mIHC/IF assays require concerted efforts to optimize and validate the multiplex staining protocols prior to their application on slides. The best practice guidelines for staining and validation of mIHC/IF assays across platforms were previously published by this task force.
View Article and Find Full Text PDFNanopore Decoding with Speed and Versatility for Data Storage.
Bioinformatics
January 2025
Department of Electrical and Computer Engineering, North Carolina State University, Raleigh, North Carolina, USA.
Motivation: As nanopore technology reaches ever higher throughput and accuracy, it becomes an increasingly viable candidate for reading out DNA data storage. Nanopore sequencing offers considerable flexibility by allowing long reads, real-time signal analysis, and the ability to read both DNA and RNA. We need flexible and efficient designs that match nanopore's capabilities, but relatively few designs have been explored and many have significant inefficiency in read density, error rate, or compute time.
View Article and Find Full Text PDFEvaluation of keratometric and total corneal astigmatism measurements from optical biometers and anterior segment tomographers and mapping to reconstructed corneal astigmatism vector components.
PLoS One
January 2025
Department of Ophthalmology, Pennsylvania State University, Hershey, PA, United States of America.
Purpose: To investigate different measures for corneal astigmatism in the context of reconstructed corneal astigmatism (recCP) as required to correct the pseudophakic eye, and to derive prediction models to map measured corneal astigmatism to recCP.
Methods: Retrospective single centre study of 509 eyes of 509 cataract patients with monofocal (MX60P) IOL. Corneal power measured with the IOLMaster 700 keratometry (IOLMK), and Galilei G4 keratometry (GK), total corneal power (TCP2), and Alpin's integrated front (CorT) and total corneal power (CorTTP).
Free-space optical spiking neural network.
PLoS One
January 2025
Department of Computer Engineering, Sharif University of Technology, Tehran, Iran.
Neuromorphic engineering has emerged as a promising avenue for developing brain-inspired computational systems. However, conventional electronic AI-based processors often encounter challenges related to processing speed and thermal dissipation. As an alternative, optical implementations of such processors have been proposed, capitalizing on the intrinsic information-processing capabilities of light.
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