A fast charge-integrating detector has been showcased for high-resolution X-ray ptychography. The advancement in developing detectors of this kind, with rapid framing capabilities, holds paramount significance in harnessing the full potential of emerging diffraction-limited synchrotron sources for X-ray nanoimaging.
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Counting on the future: fast charge-integrating detectors for X-ray nanoimaging.
J Synchrotron Radiat
September 2023
Advanced Photon Source, Argonne National Laboratory, Lemont, IL 60439, USA.
A fast charge-integrating detector has been showcased for high-resolution X-ray ptychography. The advancement in developing detectors of this kind, with rapid framing capabilities, holds paramount significance in harnessing the full potential of emerging diffraction-limited synchrotron sources for X-ray nanoimaging.
View Article and Find Full Text PDFWe have developed and demonstrated an image super-resolution method-XR-UNLOC: X-Ray UNsupervised particle LOCalization-for hard x-rays measured with fast-frame-rate detectors that is an adaptation of the principle of photo-activated localization microscopy (PALM) and stochastic optical reconstruction microscopy (STORM), which enabled biological fluorescence imaging at sub-optical-wavelength scales. We demonstrate the approach on experimental coherent Bragg diffraction data measured with 52 keV x-rays from a nanocrystalline sample. From this sample, we resolve the fine fringe detail of a high-energy x-ray Bragg coherent diffraction pattern to an upsampling factor of 16 of the native pixel pitch of 30 μm of a charge-integrating fastCCD detector.
View Article and Find Full Text PDFFast and accurate data collection for macromolecular crystallography using the JUNGFRAU detector.
Nat Methods
October 2018
Swiss Light Source, Paul Scherrer Institute, Villigen, Switzerland.
The accuracy of X-ray diffraction data is directly related to how the X-ray detector records photons. Here we describe the application of a direct-detection charge-integrating pixel-array detector (JUNGFRAU) in macromolecular crystallography (MX). JUNGFRAU features a uniform response on the subpixel level, linear behavior toward high photon rates, and low-noise performance across the whole dynamic range.
View Article and Find Full Text PDFMÖNCH detector enables fast and low-dose free-propagation phase-contrast computed tomography of in situ mouse lungs.
J Synchrotron Radiat
March 2018
Paul Scherrer Institute, 5232 Villigen PSI, Switzerland.
Due to the complexity of the underlying pathomechanism, in vivo mouse lung-disease models continue to be of great importance in preclinical respiratory research. Longitudinal studies following the cause of a disease or evaluating treatment efficacy are of particular interest but challenging due to the small size of the mouse lung and the fast breathing rate. Synchrotron-based in-line phase-contrast computed tomography imaging has been successfully applied in lung research in various applications, but mostly at dose levels that forbid longitudinal in vivo studies.
View Article and Find Full Text PDFFast integrator based data acquisition system for the SST-1 Thomson scattering system.
Rev Sci Instrum
April 2010
Institute for Plasma Research, Bhat, Gandhinagar 382 428, India.
An operational transconductance amplifier based fast charge-integrating module (FCIM) is designed and developed for an easy acquisition of fast Thomson scattered and background signal. FCIM based data acquisition technique can be used for the measurement of charge pulses of <20 ns duration. The response of the module is tested using a standard pulsed charge-generating module.
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