AI Article Synopsis

  • Cefiderocol resistance is becoming more common in Enterobacterales that produce New Delhi metallo-β-lactamase.
  • Research on Escherichia coli sequence type 361 shows mutations that contribute to this resistance in France.
  • Ongoing genomic monitoring of carbapenem-resistant Enterobacterales is necessary to better understand the spread of cefiderocol-resistant E. coli in Europe.

Article Abstract

Cefiderocol resistance is increasingly reported in New Delhi metallo-β-lactamase-producing Enterobacterales. Genomic and phenotypic analysis of Escherichia coli sequence type 361, a primary clone causing carbapenemase spread in France, revealed mutations leading to cefiderocol resistance. Continued genomic surveillance of carbapenem-resistant Enterobacterales could clarify prevalence of cefiderocol-resistant E. coli in Europe.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10461684PMC
http://dx.doi.org/10.3201/eid2909.230390DOI Listing

Publication Analysis

Top Keywords

analysis escherichia
8
escherichia coli
8
coli sequence
8
sequence type
8
type 361
8
cefiderocol resistance
8
population analysis
4
361 reduced
4
reduced cefiderocol
4
cefiderocol susceptibility
4

Similar Publications

Ensuring everyone enjoys healthy lifestyles and well-being at all ages, Progress has been made in increasing access to clean water and sanitation facilities and reducing the spread of epidemics and diseases. The synthesis of nano-particles (NPs) by using microalgae is a new nanobiotechnology due to the use of the biomolecular (corona) of microalgae as a capping and reducing agent for NP creation. This investigation explores the capacity of a distinct indigenous microalgal strain to synthesize silver nano-particles (AgNPs), as well as its effectiveness against multi-drug resistant (MDR) bacteria and its ability to degrade Azo dye (Methyl Red) in wastewater.

View Article and Find Full Text PDF

The highly rugged yet navigable regulatory landscape of the bacterial transcription factor TetR.

Nat Commun

December 2024

Department of Evolutionary Biology and Environmental Studies, University of Zurich, Winterthurerstrasse 190, Zurich, CH-8057, Switzerland.

Transcription factor binding sites (TFBSs) are important sources of evolutionary innovations. Understanding how evolution navigates the sequence space of such sites can be achieved by mapping TFBS adaptive landscapes. In such a landscape, an individual location corresponds to a TFBS bound by a transcription factor.

View Article and Find Full Text PDF

Mandatory surveillance of bacteremia conducted by automated monitoring.

Front Public Health

December 2024

Department of Data Integration and Analysis, Statens Serum Institut, Copenhagen, Denmark.

Except for a few countries, comprehensive all-cause surveillance for bacteremia is not part of mandatory routine public health surveillance. We argue that time has come to include automated surveillance for bacteremia in the national surveillance systems, and explore diverse approaches and challenges in establishing bacteremia monitoring. Assessed against proposed criteria, surveillance for bacteremia should be given high priority.

View Article and Find Full Text PDF

Background And Objectives: The incidence of multidrug-resistant, Gram-negative organisms, isolated as the etiological agents of infections is ascending. The advent of novel antibiotics poses significant challenges, necessitating the optimization and utilization of extant antimicrobial agents. Cefoperazone, a third-generation cephalosporin and β-lactam antimicrobial, when combined with sulbactam, an irreversible β-lactamase inhibitor, mitigates the vulnerability of cefoperazone to β-lactamase-producing organisms.

View Article and Find Full Text PDF

Background: Urinary retention in obstructed male cats leads to changes in blood and urine compounds, which, combined with the time of obstruction, are linked to the worsening of the animal's clinical status.

Aim: This study aimed to describe the primary laboratory changes in male cats with urethral obstruction (UO).

Methods: Medical records of 386 male cats diagnosed with UO and treated at the Veterinary Teaching Hospital of the Faculty of Veterinary Medicine and Zootechnics (FMVZ), UNESP-Botucatu, between 2010 and 2020 were reviewed.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!