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Filename: controllers/Detail.php
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Function: _error_handler
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Filename: controllers/Detail.php
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Filename: controllers/Detail.php
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Function: insertAPISummary
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The mammalian olfactory system detects and discriminates between millions of odorants to elicit appropriate behavioral responses. While much has been learned about how olfactory sensory neurons detect odorants and signal their presence, how specific innate, unlearned behaviors are initiated in response to ethologically relevant odors remains poorly understood. Here, we show that the 4-transmembrane protein CD20, also known as MS4A1, is expressed in a previously uncharacterized subpopulation of olfactory sensory neurons in the main olfactory epithelium of the murine nasal cavity and functions as a mammalian odorant receptor that recognizes compounds produced by mouse predators. While wild-type mice avoid these predator odorants, mice genetically deleted of CD20 do not appropriately respond. Together, this work reveals a novel CD20-mediated odor-sensing mechanism in the mammalian olfactory system that triggers innate behaviors critical for organismal survival.
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http://dx.doi.org/10.1101/2023.08.08.552498 | DOI Listing |
Elife
December 2024
Sorbonne Université, Centre National de la Recherche Scientifique (CNRS UMR7622), Institut de Biologie Paris-Seine (IBPS), Developmental Biology Laboratory, Paris, France.
Despite recent progress, the complex roles played by the extracellular matrix in development and disease are still far from being fully understood. Here, we took advantage of the zebrafish mutation which affects Laminin γ1, a major component of basement membranes, to explore its role in the development of the olfactory system. Following a detailed characterisation of Laminin distribution in the developing olfactory circuit, we analysed basement membrane integrity, olfactory placode and brain morphogenesis, and olfactory axon development in mutants, using a combination of immunochemistry, electron microscopy and quantitative live imaging of cell movements and axon behaviours.
View Article and Find Full Text PDFThe olfactory system employs responses of an ensemble of odorant receptors (ORs) to sense molecules and to generate olfactory percepts. Here we hypothesized that ORs can be viewed as 3D spatial filters that extract molecular features relevant to the olfactory system, similarly to the spatio-temporal filters found in other sensory modalities. To build these filters, we trained a convolutional neural network (CNN) to predict human olfactory percepts obtained from several semantic datasets.
View Article and Find Full Text PDFFront Hum Neurosci
December 2024
Faculty of Psychology, Universitas Gadjah Mada, Yogyakarta, Indonesia.
The COVID-19 pandemic has highlighted the prevalence of fatigue, reduced interpersonal interaction, and heightened stress in work environments. The intersection of neuroscience and architecture underscores how intricate spatial perceptions are shaped by multisensory stimuli, profoundly influencing workers' wellbeing. In this study, EEG and VR technologies, specifically the , were employed to gather data on perception and cognition.
View Article and Find Full Text PDFPest Manag Sci
December 2024
Department of Entomology and Plant Pathology, University of Arkansas, Fayetteville, AR, USA.
Background: While the mother knows best/preference performance hypothesis has been well tested in natural ecosystems, how these ecological principles differ in agroecosystems is less explored. In this study, we investigated the ovipositional preference and offspring performance of fall armyworm (FAW) across vegetative and reproductive stages of soybean.
Results: We examined trichomes, volatile organic compounds (VOCs) and assessed electroantennogram (EAG) measurements to understand how olfactory responses are affected by volatiles at different phenological stages during photoperiodism (photophase and scotophase).
Zoology (Jena)
December 2024
Department of Biodiversity, Ecology and Evolution, Complutense University of Madrid, Madrid, Spain.
The transition between aquatic and terrestrial habitats leads to extreme structural changes in sensorial systems. Olfactory receptors (OR) are involved in the detection of odorant molecules both in water and on land. Therefore, ORs are affected by evolutionary habitat transitions experienced by organisms.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!