The micron track conduit (MTC) and nerve factor provide a physical and biological model for simulating peripheral nerve growth and have potential applications for nerve injury. However, it has rarely been reported that they synergize on peripheral nerves. In this study, we used bioderived chitosan as a substrate to design and construct a neural repair conduit with micron track topography using threedimensional (3D) printing topography. We loaded the MTC with neurotrophin-3 (NT-3) to promote the regeneration of sensory and sympathetic neurons in the peripheral nervous system. We found that the MTC@NT3 composite nerve conduit mimicked the microenvironment of peripheral nerves and promoted axonal regeneration while inducing the targeted growth of Schwann cells, which would promote functional recovery in rats with peripheral nerve injury. Artificial nerve implants with functional properties can be developed using the strategy presented in this study.
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http://dx.doi.org/10.18063/ijb.770 | DOI Listing |
Med Phys
January 2025
Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, USA.
Purpose: In locations where the proton energy spectrum is broad, lineal energy spectrum-based proton biological effects models may be more accurate than dose-averaged linear energy transfer (LET) based models. However, the development of microdosimetric spectrum-based biological effects models is hampered by the extreme computational difficulty of calculating microdosimetric spectra. Given a precomputed library of lineal energy spectra for monoenergetic protons, a weighted summation can be performed which yields the lineal energy spectrum of an arbitrary polyenergetic beam.
View Article and Find Full Text PDFSensors (Basel)
December 2024
TDA Research Inc., Golden, CO 80403, USA.
Here we describe the synthesis and evaluation of a molecular corrosion sensor that can be applied in situ in aerospace coatings, then used to detect corrosion after the coating has been applied. A pH-sensitive molecule, 4-mercaptopyridin (4-MP), is attached to a gold nanoparticle to allow surface-enhanced Raman-scattering (SERS) for signal amplification. These SERS nanoparticles, when combined with an appropriate micron-sized carrier system, are incorporated directly into an MIL-SPEC coating and used to monitor the process onset and progression of corrosion using pH changes occurring at the metal-coating interface.
View Article and Find Full Text PDFMicromachines (Basel)
November 2024
Department of Mechanical and Manufacturing Engineering, Schulich School of Engineering, University of Calgary, 2500 University Dr. NW, Calgary, AB T2N 1N4, Canada.
This study investigates the movements of particles in an accelerated toroidal flow channel filled with water, with specific applications for a particle imaging velocimetry gyroscope (PIVG). We used computational fluid dynamics (CFD) to simulate particle behavior under different angular accelerations. These angular accelerations were 4 rad/s, 6 rad/s, and 8 rad/s for particles densities of 1100 kg/m, 1050 kg/m, and 980 kg/m.
View Article and Find Full Text PDFAnalyst
January 2025
Questrom School of Business, Boston University, Boston, MA, 02215, USA.
Latent fingerprints (LFPs) are invisible impressions that need to be developed before being used for criminal investigation; however, existing fingerprint visualization techniques face challenges, such as complex preparation and poor contrast. To advance practical fingerprint detection, green-emissive micron-sized curcumin/kaolin composites were synthesized a facile and cost-effective one-step physical cross-linking method, which exhibited unprecedented performance in developing diversified marks, including LFPs, knuckle prints, palm prints, and footprints, with clear three-level details on various substrates. Notably, the powders successfully developed LFPs that were aged for 30 days and even up to 100 days, meeting the stringent requirements for comprehensive forensic application.
View Article and Find Full Text PDFSci Rep
December 2024
Department of Bio-Environmental Chemistry, College of Agricultural and Life Science, Chungnam National University, Daejeon, 34134, South Korea.
This study explores the potential application of rice husk biochars, categorized by their pH (acidic, pH 5.98; neutral, pH 7.02; and alkali, pH 11.
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