AI Article Synopsis

  • - A patient with sigmoid colon cancer and multiple liver metastases achieved complete remission after chemotherapy and a hepatectomy, but later experienced local recurrence and underwent a second surgery.
  • - Following laparoscopic sigmoidectomy for a new adenocarcinoma diagnosed via colonoscopy, the patient received further chemotherapy which resulted in the liver metastases shrinking, allowing for a successful right hepatectomy.
  • - Despite the initial success, a follow-up revealed local recurrence of liver metastasis, leading to a partial hepatectomy; the patient is currently recurrence-free and continuing treatment with modified FOLFOX.

Article Abstract

We report a case of a patient with sigmoid colon cancer and multiple liver metastases who underwent hepatectomy after chemotherapy and pathological results showed complete remission. However, after chemotherapy was discontinued, the patient developed a local recurrence of the liver metastasis and underwent rehepatectomy. The patient came to our hospital with lower abdominal pain. Colonoscopy revealed a circumferential type Ⅱ, well-differentiated adenocarcinoma. Laparoscopic sigmoidectomy with lymph node dissection was performed. Postoperative CT scan showed multiple liver metastases at S5, S7, and S8. 11 cycles of bevacizumab plus modified FOLFOX(mFOLFOX)were subsequently performed. The liver metastases shrank at all sites, and the patient underwent right hepatectomy. The resected specimen was considered to be in complete remission, with no evidence of viable malignant cells. Postoperatively, bevacizumab plus mFOLFOX was resumed for 6 cycles and the patient remained in remission. However, 3 months after stopping chemotherapy and 1 year and 6 months after hepatectomy, a follow-up CT scan showed local recurrence of the liver edge, and a diagnosis of local recurrence of liver metastasis was made, and a partial hepatectomy was performed. The patient is recurrence-free and resuming modified FOLFOX 9 months after surgery.

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