Lethal infections are associated with cellular dysfunction as evidenced by a decrease in the resting transmembrane potential difference (Em) of skeletal muscle fibers. Endotoxin stimulation of macrophages evokes production of cachectin, a protein that has been implicated as a mediator of the lethal effects of endotoxemia. In the present study, rat skeletal muscle fiber Em decreased when incubated with recombinant human cachectin. The reduction of Em induced by cachectin occurred in a dose-related fashion and was inhibited by mAb against the monokine. Infusion of cachectin induced a decline of skeletal muscle Em in vivo, and suggests that cachectin may acutely mediate alterations of skeletal muscle membrane function after infection.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188416 | PMC |
| http://dx.doi.org/10.1084/jem.164.4.1368 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Treatment With Full-Spectrum Cannabidiol Oil Improved the Pathological Findings of Dystrophic Mutant Mice.
Muscle Nerve
January 2025
Department of Anatomy, Federal University of Alfenas (UNIFAL-MG), Alfenas, Brazil.
Introduction/aims: Duchenne muscular dystrophy (DMD) is caused by pathogenic variants in the DMD gene, making muscle fibers susceptible to contraction-induced membrane damage. Given the potential beneficial action of cannabidiol (CBD), we evaluated the in vitro effect of full-spectrum CBD oil on the viability of dystrophic muscle fibers and the in vivo effect on myopathy of the mdx mouse, a DMD model.
Methods: In vitro, dystrophic cells from the mdx mouse were treated with full-spectrum CBD oil and assessed with cell viability and cytotoxic analyses.
Mechanism of Acute Kidney Injury in Mild to Moderate Heat-related Illness.
Juntendo Iji Zasshi
December 2024
Objectives: This study focuses on mild-to-moderate severity cases to examine the triggers initiating kidney injury.
Materials: Patients aged ≥18 years with suspected heat-related illnesses at the Juntendo University Hospital Emergency and Primary Care Center between July and September 2020 and June and August 2022 were included.
Methods: Blood samples were obtained during their visit, and the patients were categorized into two groups based on their cystatin-based estimated GFR (eGFRcys) values: a kidney injury group (eGFRcys < 60 mL/min/1.
Comparative study of imputation strategies to improve the sarcopenia prediction task.
Digit Health
January 2025
Department of Exercise Rehabilitation & Welfare, Gachon University, Incheon, Republic of Korea.
Objective: Sarcopenia, a condition characterized by the progressive loss of skeletal muscle mass and strength, poses significant challenges in research due to missing data. Incomplete datasets undermine the accuracy and reliability of studies, necessitating effective imputation techniques. This study conducts a comparative analysis of three advanced methods-multiple imputation by chained equations (MICE), support vector regression, and K-nearest neighbors (KNN)-to address data completeness issues in sarcopenia research.
View Article and Find Full Text PDFControversies in fecal incontinence.
World J Gastroenterol
January 2025
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Augusta University, Augusta, GA 30912, United States.
Fecal incontinence is a common condition that can significantly impact patients' quality of life. Obstetric anal sphincter injury and anorectal surgeries are common etiologies. Endoanal ultrasound and anorectal manometry are important diagnostic tools for evaluating patients.
View Article and Find Full Text PDFHistopathology of incidental non-neoplastic findings in transgenic CByB6F1-Tg(HRAS)2Jic mice used in toxicity studies.
J Toxicol Pathol
January 2025
Labcorp Early Development Laboratories, Inc., 3635 Concorde Parkway, Suite 100, Chantilly, VA, 20151, USA.
This technical report presents a collection of illustrative images and concise descriptions of non-neoplastic microscopic findings noted in transgenic CByB6F1-Tg(HRAS)2Jic (Tg.rasH2) mice from 26-week-carcinogenicity studies. A unique finding in the Tg.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!