Rods under mechanical stress are a classic example of dynamic instability. Axis elongation in Drosophila usually leads to a U-shaped axis, but folded or twisted axes are observed in certain mutants. Analysis of these mutants now reveals the source of the instability and the mechanism for maintaining left-right symmetry.
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http://dx.doi.org/10.1016/j.cub.2023.07.007 | DOI Listing |
J Cell Mol Med
January 2025
Department of Spine, Orthopaedic Center, Guangdong Second Provincial General Hospital, Jinan University, Guangzhou, China.
Osteogenic differentiation of bone marrow stem cells (BMSCs) is essential for bone tissue regeneration and repair. However, this process is often hindered by an unstable differentiation influenced by local microenvironmental factors. While small extracellular vesicles (sEVs) derived from osteogenically induced adipose mesenchymal stem cells (ADSCs) reportedly can promote osteogenic differentiation of BMSCs, the underlying molecular mechanisms remain incompletely understood.
View Article and Find Full Text PDFDevelopment
December 2024
MRC Mammalian Genetics Unit, MRC Harwell Institute, Didcot, Oxfordshire OX11 0RD, UK.
J Bodyw Mov Ther
October 2024
University of Caxias Do Sul, Caxias Do Sul, Brazil. Electronic address:
Introduction: Pregnancy's physiological changes and weight gain can decrease balance control, increasing the risk of falls and impacting quality of life. The effect of obesity on balance control in pregnant women needs further investigation.
Objective: Investigate the effect of obesity during pregnancy on center of pressure (COP) control under sensory disturbances at different gestational age.
Mol Biol Cell
November 2024
Department of Cell and Developmental Biology, State University of New York Upstate Medical University, Syracuse, NY 13210.
Formin HOmology Domain 2-containing (FHOD) proteins are a subfamily of actin-organizing formins important for striated muscle development in many animals. We showed previously that absence of the sole FHOD protein, FHOD-1, from results in thin body wall muscles with misshapen dense bodies that serve as sarcomere Z-lines. We demonstrate here that mutations predicted to specifically disrupt actin polymerization by FHOD-1 similarly disrupt muscle development, and that FHOD-1 cooperates with profilin PFN-3 for dense body morphogenesis, and with profilins PFN-2 and PFN-3 to promote body wall muscle growth.
View Article and Find Full Text PDFBMC Ophthalmol
August 2024
Department of Science, Hamedan University of Technology, Hamedan, Iran.
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