AI Article Synopsis
- The research aimed to create a stable nimesulide emulgel using arabinoxylan, a natural gelling agent from Plantago ovata, optimizing it with response surface methodology.
- Various concentrations of arabinoxylan, span 80, and tween 20 were tested, resulting in successful formulation noted for stability, compatibility, and desired viscosity.
- The optimized emulgel demonstrated high drug release rates and effective analgesic effects without irritation, indicating its potential as an effective drug delivery system.
Article Abstract
Prime objective of the current research was to develop a stable nimesulide emulgel with the help of arabinoxylan, a natural gelling agent extracted from Plantago ovata. The response surface methodology was used by a Design Expert 10 software to formulate and optimize the emulgel. The experimental design approach evaluated the impact of independent and dependent variables. Independent variables were different concentrations of arabinoxylan, span 80 and tween 20, whereas, dependent variables were viscosity, pH, and content uniformity. FTIR demonstrated the compatibility of nimesulide with the excipients. Stability study indicated no phase separation and no change in pH for formulation F1, F3 and F4. The negative values of zeta potential revealed the excellent stability of emulgel. Viscosity, spreadability and extrudability values were in desired range. Ex-vivo permeation study illustrated 86%, 55% and 66% release of the drug over a period of 24 h from the formulations F1, F3 and F4, respectively. Analgesic effect of the optimized emulgel was significantly higher in test group as compared to control and did not produce any sort of irritation. Therefore, it can be concluded that the newly developed emulgel based on arabinoxylan, as gelling agent, appear to be an effective drug delivery system.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10443879 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0290223 | PLOS |
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