Analgesics effect of local diclofenac in third molar surgery: a randomized, controlled trial.

Clin Oral Investig

Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Chiang Mai University, Suthep, A. Muang, Chiang Mai, 50200, Thailand.

Published: October 2023

AI Article Synopsis

  • This study assessed the impact of local diclofenac application on pain and recovery after removing impacted mandibular third molars.
  • A double-blind, crossover trial with 20 patients compared diclofenac to a control (phosphate-buffered saline) on opposite sides of their mouths.
  • Results showed lower pain scores and a longer time to first pain with diclofenac, indicating its effectiveness as a postoperative analgesic with minimal side effects.

Article Abstract

Objectives: This study aimed to evaluate the effect of locally diclofenac application on postoperative pain, sequalae, and adverse effects following mandibular third molar (MTM) surgery.

Methods: A randomized, crossover, double-blind, controlled trial was conducted in 20 patients who required surgical removal of bilateral symmetrical impacted MTM at two separate appointments. The 40 MTMs were randomly allocated to two groups. One side was assigned 0.1% w/v diclofenac sodium as the diclofenac group. The contralateral side was assigned phosphate-buffered saline (PBS) as the control group. Postoperative pain intensity was measured by visual analogue scale (VAS), where the time when the first pain emerged, the time to first rescue medication, pain at 6 and 24 h after surgery, and the total number of analgesics consumed were recorded. Postoperative swelling and trismus were assessed on postoperative days 2 and 7. The differences of continuous outcomes between two groups were analyzed by paired t-test or Wilcoxon signed-rank test.

Results: VAS scores were significantly lower when the first pain emerged and 6 h after surgery in diclofenac group (p < 0.05). The onset of pain in the diclofenac group was significantly longer than in the control group (p < 0.05). Two patients reported mild nausea and dizziness in the diclofenac group.

Conclusion: This study demonstrates the analgesic effectiveness of 0.1% local application of diclofenac within 6 h postoperative with few side effects.

Clinical Relevance: Locally diclofenac application is an alternative of postoperative analgesic in MTM surgery which provides pain-free periods within 6 h.

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Source
http://dx.doi.org/10.1007/s00784-023-05221-wDOI Listing

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