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Ferroptosis-related Biotargets and Network Mechanisms of Maslinic Acid Against Myocardial Ischemia-reperfusion Injury: An Integrated Bioinformatic and Experimental Approach.
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Department of Cardiology, Tianjin First Center Hospital, Tianjin, China.
Background: Maslinic acid (MA), a pentacyclic triterpenoid compound derived from leaves and fruits of Olea europaea, bears multi-pharmacological properties. Our previous studies found that MA exerted a cardioprotective effect by modulating oxidative stress, inflammation, and apoptosis during myocardial ischemia-reperfusion injury (MIRI). Nevertheless, data regarding the anti-ferroptosis effects of MA on MI/RI remains unidentified.
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UNICEF Jamaica, Kingston, Jamaica.
Background: Intimate partner violence (IPV) and violence against children are global issues with severe consequences. Intersections shared by the 2 forms of violence have led to calls for joint programming efforts to prevent both IPV and violence against children. Parenting programs have been identified as a key entry point for addressing multiple forms of family violence.
View Article and Find Full Text PDFRisk factors for overtaking, rear-end, and door crashes involving bicycles in the United Kingdom: Revisited and reanalysed.
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Graduate Institute of Injury Prevention and Control, College of Public Health, Taipei Medical University, Taipei City, Taiwan.
Background And Objective: Relevant research has provided valuable insights into risk factors for bicycle crashes at intersections. However, few studies have focused explicitly on three common types of bicycle crashes on road segments: overtaking, rear-end, and door crashes. This study aims to identify risk factors for overtaking, rear-end, and door crashes that occur on road segments.
View Article and Find Full Text PDFHydrological dynamics of the Yangtze river-Dongting lake system after the construction of the three Gorges dam.
Sci Rep
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School of Ocean Engineering and Technology/Institute of Estuarine and Coastal Research, Sun Yat-sen University, Guangzhou, 510275, China.
The Yangtze River-Dongting Lake link has gotten a lot of attention as a because of the Three Gorges Project. However, the hydrological dynamic process and future direction of the river-lake interaction in the context of sediment reduction are yet unknown. Based on Dongting Lake Basin runoff and sediment data from 1961 to 2020, as well as field monitoring data of turbidity and flow velocity from Yichang to Chenglingji section of the Yangtze River, this paper examines the runoff and sediment variation law and hydrological dynamic process of Chenglingji, the only outlet connecting Dongting Lake to the Yangtze River, and reveals the development trend of the river-lake relationship.
View Article and Find Full Text PDFTechno-structural and 3-D geometric morphometric analysis applied for investigating the variability of Holocene unifacial tools in tropical Central Brazil.
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Département Homme & Environnement, Muséum National d'Histoire Naturelle, UMR 7194 HNHP, Équipe PRÉTROP, Musée de l'Homme, Paris, France.
During the transition from the Pleistocene to the Holocene and in the early Holocene period, hunter-gatherer communities across tropical South America deployed a range of technological strategies to adapt to diverse environmental conditions. This period witnessed a rich tapestry of technological practices, from enduring, widely disseminated tools to local and sporadically utilized technologies, shaping a multifaceted landscape of technological traditions. Lithic technology during this period was mainly marked by localized sourcing of raw materials, the use of multifunctional tools, a variety of projectile point designs, and the frequently utilization of unifacial shaping technology.
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