Environ Toxicol Pharmacol
Center of Excellence in Cardiac Electrophysiology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand; Cardiac Catheterization & Electrophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand. Electronic address:
Published: September 2023
Glyphosate-based herbicides (GBHs) containing glyphosate as the active component are extensively used worldwide. Concerns have arisen about their potential risk to human, as glyphosate has been detected in human body fluids. Current controversies surround the endocrine-disrupting properties and transgenerational inheritance of diseases and germline epimutations resulting from exposure to GBHs and glyphosate. This review discusses evidence from in vitro, in vivo, and clinical studies on their impact on sex hormone regulation and reproductive system. Evidence suggests that they act as endocrine-disrupting chemicals, which altering sex hormone levels. Mechanistically, they interfere with hormone signaling pathways by disrupting proteins involved in hormone transport and metabolism. Pathological changes have been observed in male and female reproductive systems, potentially leading to reproductive toxicity. Prenatal exposure may lead to transgenerational inheritance of pathologies and sperm epimutations. However, due to the complexity of glyphosate formulations containing adjuvants identifying higher risk components in environmental exposure becomes challenging.
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http://dx.doi.org/10.1016/j.etap.2023.104252 | DOI Listing |
J Agric Food Chem
January 2025
State Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.
Glyphosate-based herbicide (GBH), a feed contaminant, has been proven to impair the growth and development of humans and animals. Previous research has revealed that maternal toxin exposure during pregnancy could cause permanent fetal changes by epigenetic modulation. However, there was insufficient evidence of the involvement of DNA methylation in maternal GBH exposure-induced intestinal health of offspring.
View Article and Find Full Text PDFCureus
November 2024
Genotoxicology Laboratory, Universidad Autónoma de Occidente, Los Mochis, MEX.
Introduction: Extensive agricultural activity results in significant exposure to pesticides, particularly glyphosate, which has been linked to immunological disorders, including apoptosis and inflammation. , a species from the Bromeliaceaefamily native to Mexico, is traditionally used in folk medicine for its medicinal properties, including anti-inflammatory effects. This research aimed to evaluate the protective effects of extract on human peripheral blood mononuclear cells (PBMCs) exposed to Faena®, a commercially available glyphosate-based herbicide.
View Article and Find Full Text PDFADMET DMPK
December 2024
Department of Forensic Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand.
Background And Purpose: Glyphosate-based herbicides, extensively utilized worldwide, raise concerns regarding potential human risks due to the detection of glyphosate (GLY) in human body fluids. This study aims to address critical knowledge gaps regarding whether GLY undergoes metabolism in humans, particularly considering the limited information available on human metabolism.
Experimental Approach: The study investigated GLY and its metabolites in eight amenity horticultural workers using proton nuclear magnetic resonance (H-NMR) data analysis.
Environ Sci Pollut Res Int
January 2025
Laboratório de Ecologia e Conservação, Universidade Federal da Fronteira Sul, Campus Erechim, RS 135 - km 72, nº 200, Erechim, RS, Brazil.
Atrazine and glyphosate are considered some of the main pollutants for aquatic ecosystems, directly and indirectly affecting non-target organisms, such as amphibians. This study aimed to evaluate the sublethal effects of different concentrations of atrazine-based herbicide (ABH) and glyphosate-based herbicide (GBH) commercial formulations, both individually and in a mixture, through toxicity tests on the larval stage of Boana faber. Tadpoles were exposed to concentrations of ABH (2, 9.
View Article and Find Full Text PDFChemosphere
February 2025
Universidade Federal de Minas Gerais, Instituto de Ciências Exatas, Departamento de Química. Av. Antônio Carlos, 6627, Belo Horizonte, Minas Gerais, Brazil. Electronic address:
Metabolomics is a valuable tool to assess glyphosate exposure and its potential impact on human health. However, few studies have used metabolomics to evaluate human exposure to glyphosate or glyphosate-based herbicides (GBHs). In this study, an untargeted and targeted metabolomics approach was applied to human skin fibroblasts exposed to the GBH Roundup (GLYP-R).
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