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On-chip non-contact mechanical cell stimulation - quantification of SKOV-3 alignment to suspended microstructures.
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Electrical and Computer Engineering, University of Canterbury, Christchurch, New Zealand.
Although the accumulation of random genetic mutations has been traditionally viewed as the main cause of cancer progression, altered mechanobiological profiles of the cells and microenvironment also play a major role as a mutation-independent element. To probe the latter, we have previously reported a microfluidic cell-culture platform with an integrated flexible actuator and its application for sequential cyclic compression of cancer cells. The platform is composed of a control microchannel in a top layer for introducing external pressure, and a polydimethylsiloxane (PDMS) membrane from which a monolithically-integrated actuator protrudes downwards into a cell-culture microchannel.
View Article and Find Full Text PDFAim: The Transorbital and supraorbital minimally invasive approaches have been defined to reach intraorbital structures, adjacent sinuses, skull base, and other intracranial targets in this region. These approaches reduce the possible cosmetic and brain retraction-related morbidities caused by traditional transcranial approaches. Although these pathways are being studied endoscopically, a stereotactic approach has not been defined.
View Article and Find Full Text PDFThermal- and Rate-Regulated Fast Switchable Adhesion within Glass Transition Zone of an Epoxy Polymer.
Langmuir
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Institute of Advanced Manufacturing Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Changzhou 213164, People's Republic of China.
Thermoresponsive shape memory polymer (SMP) adhesives have demonstrated a high adhesion strength and large switching ratios on different substrates. However, a long response time to switch adhesion on or off is generally encountered. This study provides a fast adhesion switching method based on the temperature and rate dependence of adhesion within the glass-transition zone of an epoxy polymer.
View Article and Find Full Text PDFCellular signalling protrusions enable dynamic distant contacts in spinal cord neurogenesis.
Biol Open
January 2025
Faculty of Biology Medicine and Health, The University of Manchester, Manchester M13 9PT, UK.
In the developing mouse ventral spinal cord, HES5, a transcription factor downstream of Notch signalling, is expressed as evenly spaced clusters of high HES5-expressing neural progenitor cells along the dorsoventral axis. While Notch signalling requires direct membrane contact for its activation, we have previously shown mathematically that contact needs to extend beyond neighbouring cells for the HES5 pattern to emerge. However, the presence of cellular structures that could enable such long-distance signalling was unclear.
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