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Caspase 5 depletion is linked to hyper-inflammatory response and progeroid syndrome. | LitMetric

AI Article Synopsis

Article Abstract

A progeroid family was found to harbor a pathogenic variant in the CASP5 gene that encodes inflammatory caspase 5. Caspase 5-depleted fibroblasts exhibited hyper-activation of inflammatory cytokines in response to pro-inflammatory stimuli. Long-term intermittent hyper-inflammatory response is likely the cause of the accelerated aging phenotype comprised of earlier onset of common aging diseases, supporting inflammaging as a potential common disease mechanism of progeroid syndromes and possibly normative aging.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10828386PMC
http://dx.doi.org/10.1007/s11357-023-00907-1DOI Listing

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