Gold-Catalyzed C-O Cross-Coupling Reactions of Aryl Iodides with Silver Carboxylates.

Org Lett

Key Laboratory of Science and Technology of Eco-Textiles, Ministry of Education, College of Chemistry and Chemical Engineering, Donghua University, Shanghai 201620, China.

Published: September 2023

We have developed a C-O cross-coupling reaction of (hetero)aryl iodides with silver carboxylates via a Au/Au catalytic cycle. The transformation featured exclusive chemoselectivity and moisture/air insensitivity. Aromatic and aliphatic (including primary, secondary, and tertiary) silver carboxylates are all suitable substrates. Moreover, this protocol worked well intermolecularly and intramolecularly. Most importantly, good yields were obtained regardless of the substrates' electronic effect and steric hindrance.

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http://dx.doi.org/10.1021/acs.orglett.3c02254DOI Listing

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