AI Article Synopsis
- The study aimed to investigate the distribution of chlamydial serovars in patients with follicular conjunctivitis in Iran, linking anatomical tropism of the bacterium to its types based on outer membrane proteins.
- A total of 68 conjunctival specimens were analyzed, revealing that 55.9% of patients tested positive for Chlamydia, particularly among younger individuals, with 38.2% having a history of urinary tract infections.
- Four serovars were identified, with serovar E being the most common, suggesting that chlamydial follicular conjunctivitis often originates from genital infections and highlights the need for genotyping in understanding disease epidemiology and treatment outcomes.
Article Abstract
Objectives: infects the urogenital tract and eyes. Anatomical tropism is correlated with serovars which are characterized according to the variation in the major outer membrane proteins encoded by the gene. The aim of the present study was to determine the distribution of serovars among patients with follicular conjunctivitis in Iran.
Materials And Methods: A total of 68 conjunctival specimens from symptomatic adults were studied for the presence of using polymerase chain reaction (PCR) analysis. Serovars were determined by Omp1 PCR-RFLP analysis.
Results: was detected in 38 (55.9%) of patients with follicular conjunctivitis, with higher prevalence in the younger age groups. Twenty-six (38.2%) of these patients had a history of urinary tract infection. Four distinct serovars were identified in the conjunctiva samples using molecular genotyping. The most prevalent was serovar E, followed by G, I, and F.
Conclusion: Our serovar distribution indicated that chlamydial follicular conjunctivitis usually has a genital source. Genital serovars may cause eye diseases, especially in sexually active adults. On the other hand, conjunctivitis might be the only sign of sexually transmitted infection. Therefore, genotyping in ocular and genital specimens could be beneficial for acquiring more detailed epidemiological information about the etiology of the disease and monitoring treatment success.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10442745 | PMC |
| http://dx.doi.org/10.4274/tjo.galenos.2022.12080 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Impact of trachoma elimination efforts in afar regional state, Ethiopia: survey findings from 26 evaluation units.
BMC Infect Dis
January 2025
Ethiopia Ministry of Health, Addis Ababa, Ethiopia.
Background: Following interventions to eliminate trachoma in the Afar region of Ethiopia, our goal was to reassess the prevalence of trachomatous trichiasis (TT) and trachomatous inflammation-follicular (TF) at the woreda level, and to identify factors associated with the disease.
Methods: Cross-sectional community-based surveys were conducted in 26 trachoma-endemic woredas, employing a standardized approach. Households were selected as the secondary sampling unit.
Trachoma Impact Survey Results from 31 Woredas in Tigray Region, Ethiopia.
Ophthalmic Epidemiol
December 2024
Light for the World, Addis Ababa, Ethiopia.
Purpose: Baseline surveys were conducted in Tigray region, Ethiopia, in 2013. Since then, rounds of azithromycin mass drug administration (MDA) have been delivered in-line with international guidance. The purpose of these surveys was to assess trachomatous inflammation-follicular (TF) prevalence following those treatments to enable the region to plan the next steps towards elimination of trachoma.
View Article and Find Full Text PDFPossible viral agents to consider in the differential diagnosis of blepharoconjunctivitis.
World J Virol
December 2024
Department of Ophthalmology, University Hospital of Udine, Udine 33100, Italy.
Background: Blepharoconjunctivitis poses a diagnostic challenge due to its diverse etiology, including viral infections. Blepharoconjunctivits can be acute or chronic, self-limiting, or needing medical therapy.
Aim: To review possible viral agents crucial for accurate differential diagnosis in cases of blepharoconjunctivitis.
Seroepidemiology of trachoma in a low prevalence region receiving annual mass azithromycin distribution in Maradi, Niger.
PLoS Negl Trop Dis
December 2024
Francis I. Proctor Foundation, University of California, San Francisco, California, United States of America.
Background: Trachoma programs use the indicator trachomatous inflammation--follicular (TF) to monitor indication for and response to treatment for trachoma at the district level. Alternative indicators, including serologic markers, are increasingly being evaluated for trachoma surveillance. We evaluated seroprevalence of IgG antibodies to the Pgp3 antigen in two districts in Maradi, Niger thought to have low TF prevalence.
View Article and Find Full Text PDFOngoing transmission of trachoma in low prevalence districts in Mozambique: results from four cross-sectional enhanced impact surveys, 2022.
Sci Rep
October 2024
RTI International, Research Triangle Park, USA.
Article Synopsis
- Mozambique is progressing in eliminating trachoma, but some districts still have TF prevalence above the 5% threshold despite interventions like antibiotic distribution.
- A study in August 2022 tested residents in four districts for trachoma and other factors like water and hygiene, focusing on children aged 1-9 years.
- Findings showed TF prevalence between 1.1% and 6.0%, with lower prevalence in three districts, while seroprevalence and transmission rates varied, providing valuable data for monitoring trachoma programs.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!