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| http://dx.doi.org/10.4103/ojo.ojo_296_22 | DOI Listing |
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Adult-onset retinoblastoma: An uncommon and challenging diagnosis.
Oman J Ophthalmol
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Department of Ophthalmology, Obafemi Awolowo University, Ile-Ife, Nigeria.
Retinoblastoma in Adults: Clinical Features, Gene Mutations and Treatment Outcomes: .
Front Oncol
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Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Medical Artificial Intelligence Research and Verification Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Purpose: To report six Asian adult patients with retinoblastoma (RB).
Design: Retrospective and observational small case series.
Participants: Six patients with a white dome-shaped tumor of the retina were evaluated from May 10, 1995, to September 10, 2021.
Smad4 deficiency substitutes Cdkn2b but not Cdkn2a downregulation in pancreatic cancer following induction of genetic events in adult mice.
Pancreatology
March 2021
Laboratory of Animal Tumor Models/Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China; Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China; KIZ-SU Joint Laboratory of Animal Model and Drug Development, College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu, China. Electronic address:
Background: Minor progress in pancreatic cancer treatment and prognosis implies that more reliable animal models are urgently needed to decipher its molecular mechanisms and preclinical research. We recently reported a genetically engineered adult mouse model where Cdkn2b downregulation was required together with Cdkn2a downregulation to inactivate the Rb pathway. Besides, the role of Smad4, which is mutated more frequently than Cdkn2b in human pancreatic cancer, was determined critical on the development of the pancreas tumor by some reports.
View Article and Find Full Text PDFCase Report: Adult Retinoblastoma Progression in 19 Months.
Optom Vis Sci
November 2020
School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin.
Significance: Retinoblastoma is the most common intraocular malignancy in childhood, comprising 4% of all pediatric cancers. Adult onset is extremely rare. Enucleation is usually performed in adult cases because of the atypical presentations and malignant features of the tumor, which lead to misdiagnosis.
View Article and Find Full Text PDFEpidemiological profile of retinoblastoma in North India: Implications for primary care and family physicians.
J Family Med Prim Care
June 2020
Department of Community Medicine and School of Public Health, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Background: Retinoblastoma is the most common primary intraocular malignancy among children. Despite being curable in early stages, majority of the cases in India present in late stages, when outcomes are very poor.
Objectives: The aim of this study was to assess the epidemiological profile, clinical characteristics, and treatment practices among retinoblastoma patients in north India.
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