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Leukaemic cells expressing ETV6::FRK are sensitive to dasatinib in vivo. | LitMetric

AI Article Synopsis

Article Abstract

ETV6::Fyn-related kinase (FRK), which is a Src family tyrosine-kinase-related fusion gene and firstly identified in our patient with paediatric high risk B cell precursor acute lymphoblastic leukaemia (B-ALL), has no evidence of efficacy of tyrosine kinase inhibitor in vivo. We performed functional analysis of ETV6::FRK to establish molecular targeting therapy and determined that dasatinib could abrogate proliferation activity of ETV6::FRK through the repression of FRK-STAT3/STAT5 pathway in vitro and significantly extended the survival time of the xenografted mice in vivo ( < 0.01). Our data support the potential of dasatinib as a therapeutic option for patients with B-ALL harboring FRK rearrangements.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10435712PMC
http://dx.doi.org/10.1002/jha2.701DOI Listing

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