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Levels of inflammatory markers are differentially expressed in sickle cell anemia and sickle cell trait. | LitMetric

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Article Abstract

Although sickle cell anemia (SCA) is related to inflammation, the profile of inflammatory markers in sickle cell trait (SCT) is poorly studied. This is a cross-sectional study of inflammatory biomarkers carried out involving adults with SCA in steady state, SCT and controls. The SCA group had higher levels of lactato dehydrogenase, IL-1β, IL-6, IL-10, and tumor necrosis factor alpha than the others, while the SCT group had similar levels to control group. In addition, SCA group had lower IL-8/IL-10 and soluble triggering receptor expressed on myeloid cells-1/IL-10 ratios. These findings indicate that individuals with SCT do not have a chronic inflammatory profile and reinforce that cytokines are involved in the maintenance of the inflammatory state in SCA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10435695PMC
http://dx.doi.org/10.1002/jha2.712DOI Listing

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Descriptive epidemiology demonstrating the All of Us database as a versatile resource for the rare and undiagnosed disease community.

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