AI Article Synopsis
- Methotrexate-related lymphoproliferative disorders (MTX-LPDs) are rare but can occur in patients with rheumatoid arthritis and other conditions like psoriasis and T-cell lymphoma after methotrexate treatment.
- A case study highlights a 72-year-old woman with granulomatous mycosis fungoides who developed Epstein-Barr virus-positive diffuse large B-cell lymphoma while on methotrexate.
- The article suggests that new or unusual skin nodules in patients with cutaneous T-cell lymphoma receiving long-term methotrexate should be investigated as they could indicate MTX-LPDs.
Article Abstract
Methotrexate-related lymphoproliferative disorders (MTX-LPDs) are immunodeficiency diseases following methotrexate (MTX) administration, mainly occurring in rheumatoid arthritis patients. Although uncommon, MTX-LPDs have been reported in some patients with psoriasis, dermatomyositis, and cutaneous T-cell lymphoma (CTCL) who received MTX. Granulomatous mycosis fungoides (GMF) is a rare subtype of cutaneous T-cell lymphoma, where MTX is one of the treatment options in recalcitrant cases. Herein, we report a case of a 72-year-old female patient with GMF who additionally developed cutaneous Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphoma (DLBCL) during MTX treatment. According to the 5th edition of the WHO classification of Haematolymphoid Tumors (WHO-HAEM), this condition is currently categorized as "lymphoma arising in immunodeficiency/dysregulation". In this article, we also reviewed published literature on cutaneous MTX-LPDs in the setting of CTCL. This entity should be considered in cases of new, atypical skin nodules and/or plaques in CTCL patients receiving long-term MTX treatment.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10439773 | PMC |
| http://dx.doi.org/10.2147/CCID.S419534 | DOI Listing |
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