AI Article Synopsis
- Bladder cancer is a serious disease that often comes back after treatment, so researchers want to find new ways to help patients live longer.
- They studied a lot of data to find key genes that can predict how well a patient will do with bladder cancer.
- One important gene, called XPO1, was found to play a big role, and a drug called Selinexor that targets this gene was shown to slow down bladder cancer in tests.
Article Abstract
Objective: Bladder cancer is a clinical and social conundrum due to its high incidence and recurrence rate. It is urgent to find new targets for the diagnosis and treatment of bladder cancer and improve the prognosis and survival rate of bladder cancer patients. We sought a prognosis-related gene, built related models of evaluated bladder cancer and identified the function of the hub gene in bladder cancer.
Methods: We downloaded the data of bladder cancer patients from the TCGA database, and used differentially expressed genes (DEGs), copy number variation (CNV) and survival analysis to scan the hub genes associated with prognosis in bladder cancer. Then, multi-factor cox regression was used to obtain the bladder cancer prognosis correlation model. Then, we analyzed the relationship between the expression of hub gene and immune microenvironment of bladder cancer. The relationship between the expression of hub gene and prognosis in bladder cancer patients was verified by immunohistochemistry. Cell proliferation assay and drug sensitivity test were used to verify the inhibition of bladder cancer by targeted inhibitors.
Results: In bladder cancer, we screened seven hub genes () associated with survival. Moreover, the multifactor regression model constructed with hub gene can well distinguish the prognosis of bladder cancer. Hub gene is mostly associated with immune microenvironment. Immunohistochemical results basically confirmed the importance of XPO1 in bladder cancer. Selinexor (an inhibitor of XPO1) could effectively inhibit the proliferation of bladder cancer in the cell proliferation experiments by CCK-8 assays and it could suppress the growth of bladder cancer in mouse bladder cancer model.
Conclusions: In this study, a prognostic model with seven hub genes has provided great help for the prognosis prediction of bladder cancer patients. And is an important target affecting the prognosis of bladder cancer, and inhibition of can effectively inhibit bladder cancer proliferation and growth.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10439716 | PMC |
| http://dx.doi.org/10.7717/peerj.15670 | DOI Listing |
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