Recently, hyperpolarized substrates generated through dynamic nuclear polarization have been introduced to study metabolism. Injection of hyperpolarized [1-C]pyruvate, the most widely used substrate, allows detection of time courses of [1-C]pyruvate and its metabolic products, such as [1-C]lactate and C-bicarbonate, in various organs. However, quantitative metabolic modeling of data to measure specific metabolic rates remains challenging without measuring the input function. In this study, we demonstrate that the input function of [1-C]pyruvate can be measured in the rat carotid artery using an implantable coil.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10438913 | PMC |
| http://dx.doi.org/10.1007/s00723-012-0348-3 | DOI Listing |
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