Immunologic and nonimmunologic sclerodermal skin conditions - review.

Front Immunol

Multidisciplinary Integrated Center of Dermatological Interface Research MIC-DIR (Centrul Integrat Multidisciplinar de Cercetare de Interfata Dermatologica - CIM-CID), "Dunărea de Jos" University, Galaţi, Romania.

Published: February 2024

AI Article Synopsis

  • * These lesions have been linked to autoimmune diseases (like generalized morphea and chronic graft versus host disease), tissue storage diseases, metabolic disorders, and some progeroid syndromes.
  • * Accurate diagnosis is crucial for distinguishing these lesions from each other to ensure the right treatment is administered.

Article Abstract

Scleroderma-like cutaneous lesions have been found in many pathological conditions and they have the clinical appearance of sclerotic or scleroatrophic lesions. Affected skin biopsies described histopathological changes similar to those of scleroderma located strictly on the skin or those of systemic sclerosis. These skin lesions can be found in inflammatory diseases with autoimmune substrate (generalized morphea, chronic graft versus host disease, eosinophilic fasciitis), tissue storage diseases (scleredema, scleromyxedema, nephrogenyc systemic fibrosis, systemic amyloidosis), metabolic diseases (porphyrya cutanea tarda, phenylketonuria, hypothyroidism, scleredema diabeticorum), progeroid syndromes. Given the multiple etiologies of sclerodermal lesions, a correct differential diagnosis is necessary to establish the appropriate treatment.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10432860PMC
http://dx.doi.org/10.3389/fimmu.2023.1180221DOI Listing

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