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Author Correction: Reduced glutathione level in the aqueous humor of patients with primary open-angle glaucoma and normal-tension glaucoma.
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Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.
Distinct Metabolic Profiles of Ocular Hypertensives in Response to Hypoxia.
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Department of Drug Design and Pharmacology, University of Copenhagen, 2100 Copenhagen, Denmark.
Glaucoma is a neurodegenerative disease that affects the retinal ganglion cells (RGCs). The main risk factor is elevated intraocular pressure (IOP), but the actual cause of the disease remains unknown. Emerging evidence indicates that metabolic dysfunction plays a central role.
View Article and Find Full Text PDFReduced glutathione level in the aqueous humor of patients with primary open-angle glaucoma and normal-tension glaucoma.
NPJ Aging
November 2023
Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.
Glaucoma is a leading cause of blindness worldwide in older people. Profiling the aqueous humor, including the metabolites it contains, is useful to understand physiological and pathological conditions in the eye. In the current study, we used mass spectrometry (MS) to characterize the aqueous humor metabolomic profile and biological features of patients with glaucoma.
View Article and Find Full Text PDFDiscovery of a normal-tension glaucoma-suspect rhesus macaque with craniocerebral injury: Hints of elevated translaminar cribrosa pressure difference.
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Epigenetics in glaucoma: a link between histone methylation and neurodegeneration.
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Department of Ophthalmology, Stanford University School of Medicine, Palo Alto, California, USA.
Normal-tension glaucoma is a form of optic nerve degeneration that is characterized by loss of retinal ganglion cells independent of eye pressure elevation. In this issue of the JCI, Pan et al. report the discovery in a Japanese family of a mutation in the METTL23 gene, which encodes a histone arginine methyltransferase that causes normal-pressure glaucoma in haploinsufficiency.
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