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Digital Health for Asthma Management: Electronic Medication Monitoring for Adherence as a Case Example.
J Allergy Clin Immunol Pract
January 2025
Breathing Institute, Children's Hospital Colorado, Department of Pediatrics, Pediatric Pulmonary and Sleep Medicine Section, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO. Electronic address:
Digital health is an umbrella term for components of healthcare utilizing computer platforms, software, connectivity and sensors to augment the recording, documentation and communication of clinical information. The functions of digital health may be viewed in three domains: 1) the repository for patient information, 2) monitoring devices and 3) communication tools. Monitoring devices have provided robust information as diagnostic and prognostic tools in office and hospital settings.
View Article and Find Full Text PDFProtocol to infer off-target effects of drugs on cellular signaling using interactome-based deep learning.
STAR Protoc
January 2025
Department of Cell and Molecular Biology, SciLifeLab, Karolinska Institutet, 171 77 Stockholm, Sweden. Electronic address:
Drugs that target specific proteins often have off-target effects. We present a protocol using artificial neural networks to model cellular transcriptional responses to drugs, aiming to understand their mechanisms of action. We detail steps for predicting transcriptional activities, inferring drug-target interactions, and explaining the off-target mechanism of action.
View Article and Find Full Text PDFRational engineering of DNA-nanoparticle motor with high speed and processivity comparable to motor proteins.
Nat Commun
January 2025
Institute for Molecular Science, National Institutes of Natural Sciences, Okazaki, Aichi, Japan.
DNA-nanoparticle motor is a burnt-bridge Brownian ratchet moving on RNA-modified surface driven by Ribonuclease H (RNase H), and one of the fastest nanoscale artificial motors. However, its speed is still much lower than those of motor proteins. Here we resolve elementary processes of motion and reveal long pauses caused by slow RNase H binding are the bottleneck.
View Article and Find Full Text PDFDigital Age Transformation in Patient-Physician Communication: 25-Year Narrative Review (1999-2023).
J Med Internet Res
January 2025
University of Nebraska at Omaha, Omaha, NE, United States.
Background: The evolution of patient-physician communication has changed since the emergence of the World Wide Web. Health information technology (health IT) has become an influential tool, providing patients with access to a breadth of health information electronically. While such information has greatly facilitated communication between patients and physicians, it has also led to information overload and the potential for spreading misinformation.
View Article and Find Full Text PDFDevelopment and Validation of a Highly Sensitive Isotope-Coded Equivalent Reporter Ion Assay for the Semi-Quantification of Isocoumarins in Complex Matrices.
Anal Chem
January 2025
China-Croatia Belt and Road Joint Laboratory on Biodiversity and Ecosystem Services, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610213, China.
The accurate quantification of multicomponents using LC-MS is pivotal for ensuring the quality control of herbal medicine, as well as the investigation of their analysis of biological tissue distribution. However, two significant challenges persist: the scarcity of authentic standards and the selection of appropriate internal standards. In this study, we present a highly sensitive isotope-coded equivalent reporter ion assay (iERIA) that combines equivalently quantitative ion and isotope-coded derivatization strategies.
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