AI Article Synopsis
- The study examined factors influencing meniscus volume in knees without visible symptoms or signs of osteoarthritis.
- At the start and after five years, data was collected from participants, focusing on elements like age, BMI, and knee injuries through MRI scans.
- It found that both modifiable factors (like BMI and physical activity) and non-modifiable factors (like age and previous injuries) significantly impacted meniscus volume and its decrease over time.
Article Abstract
Objectives: To explore factors that were associated with meniscus volume in knees free of radiographic osteoarthritis (OA) features and symptoms of OA.
Methods: In the third Rotterdam Study cohort, clinical, radiographic, and magnetic resonance data were obtained at baseline (BL) and after 5 years of follow-up. Meniscus volumes and their change over time were calculated after semi-automatic segmentation on Magnetic Resonance Imaging. Knees with radiographic OA features (Kellgren and Lawrence>0) or clinical diagnosis of OA (American College of Rheumatology) at BL were excluded. Ten OA risk factors were adjusted in the multivariable analysis (generalized estimating equations), treating two knees within subjects as repeated measurements.
Results: From 1065 knees (570 subjects), the average (standard deviation) age and Body mass index (BMI) of included subjects were 54.3 (3.7) years and 26.5 (4.4) kg/m. At BL, nine factors (varus alignment, higher BMI, meniscus pathologies, meniscus extrusion, cartilage lesions, injury, greater physical activity level, quadriceps muscle strength, and higher age) were significantly associated with greater meniscus volume. Five factors (injury, meniscus pathologies, meniscus extrusion, higher age, and change of BMI) were significantly associated with meniscus volume loss.
Conclusions: Modifiable factors (varus alignment, BMI, physical activity level, and quadriceps muscle strength) and non-modifiable factors (higher age, injury, meniscus pathologies, meniscus extrusion, and cartilage lesions) were all associated with meniscus volume or meniscus volume loss over time.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.joca.2023.08.003 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Treatment with a superoxide dismutase mimetic for joint preservation during 35 and 75 days in orbit aboard the international space station, and after 120 days recovery on Earth.
Life Sci Space Res (Amst)
February 2025
Department of Radiation Oncology, Wake Forest University School of Medicine. Winston-Salem, NC, USA. Electronic address:
Reduced weight-bearing during spaceflight has been associated with musculoskeletal degradation that risks astronaut health and performance in transit and upon reaching deep space destinations. Previous rodent experiments aboard the international space station (ISS) have identified that the spaceflight-induced molecular arthritic phenotype was characterized with an increase in oxidative stress. This study evaluated if treatment with a superoxide dismutase (SOD) mimetic on orbit could prevent spaceflight-induced damage to the knee and hip articular cartilage, and the menisci in rodents.
View Article and Find Full Text PDFDamage due to ice crystallization.
Sci Rep
January 2025
Van der Waals-Zeeman institute, Institute of Physics, University of Amsterdam, Science Park 904, 1098 XH, Amsterdam, The Netherlands.
The freezing of water is one of the major causes of mechanical damage in materials during wintertime; surprisingly this happens even in situations where water only partially saturates the material so that the ice has room to grow. Here we perform freezing experiments in cylindrical glass vials of various sizes and wettability properties, using a dye that exclusively colors the liquid phase; this allows precise observation of the freezing front. The visualization reveals that damage occurs in partially water-saturated media when a closed liquid inclusion forms within the ice due to the freezing of the air/water meniscus.
View Article and Find Full Text PDFLocomoting non-magnetic marbles through meniscus emerged on the water surface using a magnetically actuated ferrofluid marble under pulsating and steady magnetic fields.
Soft Matter
January 2025
Center of Excellence in Energy Conversion (CEEC), Department of Mechanical Engineering, Sharif University of Technology, Tehran, Iran.
Recent progress in digital microfluidics has revealed the distinct advantages of liquid marbles, such as minimal surface friction, reduced evaporation rates, and non-wettability compared to uncoated droplets. This study provides a comprehensive examination of an innovative technique for the precise, contamination-free manipulation of non-magnetic water liquid marbles (WLMs) carried by a ferrofluid liquid marble (FLM) under the control of direct current (DC) and pulse-width modulation (PWM) magnetic fields. The concept relies on the phenomenon in which an FLM and WLMs form a shared meniscus when placed together on a water surface, causing the WLMs to closely track the magnetically actuated FLM.
View Article and Find Full Text PDFSpatial and temporal evaluation of iodine uptake and radiodensity in meniscus tissue using contrast-enhanced micro-CT.
Heliyon
December 2024
Empa - Swiss Federal Laboratories for Materials Science and Technology, 8600, Dübendorf, Switzerland.
Rationale And Objective: The visualization of soft tissues, like the meniscus, through X-ray micro-computed tomography (micro-CT), requires the use of contrast agents (CAs). While other studies have investigated CA diffusion in fibrocartilagineous tissues, this work aimed to optimize iodine staining protocols for meniscal tissue that improve their visualization by micro-CT. Specific objectives included evaluating the diffusion of CAs within meniscal samples over time, assessing volume changes due to staining, and identifying the iodine ions absorbed by the tissue.
View Article and Find Full Text PDFAssociation between meniscal extrusion and disease severity in knee osteoarthritis: a retrospective case-control study.
BMC Musculoskelet Disord
December 2024
Department of Orthopedics, The Second Affiliated Hospital of Air Force Military Medical University (Tangdu Hospital), 569 Xinsi Road, Baqiao District, Xi'an City, Shaanxi Province, 710000, China.
Objective: To explore the relationship between meniscus compression and the severity of knee osteoarthritis.
Materials And Methods: A retrospective case-control study included 95 patients with knee osteoarthritis (OA) admitted to our hospital from April 2021 to July 2023, who were grouped into slight protrusion of meniscus group (n = 48) and severe protrusion of meniscus group (n = 47) according to the degree of meniscal extrusion. Various parameters, including Kellgren/Lawrence classification, imaging findings, cartilage damage grading, physical function assessments, and correlation analyses, were used to evaluate the relationship between meniscal extrusion and disease progression.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!