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Exceptional stability of the sugammadex-solasodine complex: Insights from experimental and theoretical studies.
Carbohydr Polym
January 2025
Department of Pharmacognosy, Faculty of Pharmacy, Semmelweis University, Üllői út. 26, 1085 Budapest, Hungary; Integrative Health and Environmental Analysis Research Laboratory, Department of Analytical Chemistry, Institute of Chemistry, ELTE Eötvös Loránd University, Pázmány Péter sétány 1/a, 1117 Budapest, Hungary. Electronic address:
Sugammadex (SGM) is the first cyclodextrin (CD)-based selective relaxant binding agent. We investigated its ability to capture natural aminosteroid phytotoxins, and assessed its potential as an antidote for intoxication. Solasodine (SS), a toxic alkaloid from the Solanaceae family, was chosen as the model compound.
View Article and Find Full Text PDFResidual neuromuscular block in the postanaesthesia care unit: a single-centre prospective observational study and systematic review.
Br J Anaesth
October 2024
Department of Surgery, Radboud University Medical Centre, Nijmegen, The Netherlands
Background: Concerns regarding residual neuromuscular block (RNMB) have persisted since the introduction of neuromuscular blocking agents, with reported incidences in the 21st century up to 50%. Advances in neuromuscular transmission (NMT) monitoring and the introduction of sugammadex have addressed this issue, but the impact of these developments remains unclear.
Methods: This prospective observational study evaluated RNMB in 500 surgical patients in a large Dutch teaching hospital with readily available quantitative NMT monitoring and reversal agents.
Anesthesia Providers' Knowledge of Medication Interference with Hormonal Contraception: A Multisite Survey.
Anesth Analg
January 2025
Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota.
Background: Sugammadex, aprepitant, and fosaprepitant are increasingly used perioperatively. These medications may interfere with the effectiveness of hormonal contraception. This study assessed anesthesia providers' use of sugammadex and aprepitant, their knowledge of interactions with hormonal birth control, and patient counseling practices to identify possible knowledge gaps or opportunities for practice improvement.
View Article and Find Full Text PDFSugammadex vs Neostigmine, a Comparison in Reversing Neuromuscular Blockade: A Narrative Review.
Cureus
July 2024
Sports Medicine, Abhinav Bindra Targeting Performance, Bangalore, IND.
The use of neuromuscular blocking agents (NMBA) has grown due to the development of laparoscopic and minimally invasive procedures. Respiratory insufficiency, an elevated risk of aspiration, postoperative pulmonary complications, and subsequent reintubation are among the risks linked to the residual block. The normal clinical practice calls for the pharmacologic "reversal" of these agents with either sugammadex or neostigmine prior to extubation.
View Article and Find Full Text PDFEliminating residual neuromuscular blockade: a literature review.
Ann Transl Med
August 2024
Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI, USA.
Background And Objective: Although millions of patients receive neuromuscular blocking agents (NMBAs) each year as part of an anesthetic, residual neuromuscular blockade (NMB) remains a too-frequent occurrence and its adverse consequences continue to negatively impact patient outcomes. The goal of this manuscript is to provide clinicians with the information they need to decrease the incidence of residual NMB.
Methods: Published literature was reviewed and incorporated into the narrative as appropriate.
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