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Effect of weight loss on knee joint synovitis over 48 months and mediation by subcutaneous fat around the knee: data from the Osteoarthritis Initiative.
BMC Musculoskelet Disord
April 2024
Department of Radiology and Biomedical Imaging, University of California, 185 Berry St, Suite 350, Lobby 6, San Francisco, CA, 94143, USA.
Article Synopsis
- - Obesity leads to osteoarthritis development through low-grade inflammation, where synovitis (joint inflammation) worsens with weight gain, particularly in overweight and obese women.
- - A study involving 234 participants analyzed the impact of over 10% weight loss on synovitis, measuring changes through MRI over 48 months and considering subcutaneous fat around the knee.
- - Results indicated that weight loss significantly reduced the progression of effusion-synovitis but increased Hoffa-synovitis progression, with changes in subcutaneous fat mediating part of this effect, highlighting the complex relationship between weight management and joint health.
Joint-adjacent subcutaneous adipose tissue - An obesity-related imaging biomarker associated with structural osteoarthritis progression?
Osteoarthritis Cartilage
November 2023
Department for Imaging and Functional Musculoskeletal Research, Institute of Anatomy and Cell Biology, Paracelsus Medical University Salzburg and Nuremberg, Salzburg, Austria; Ludwig Boltzmann Institute for Arthritis and Rehabilitation, Paracelsus Medical University Salzburg and Nuremberg, Salzburg, Austria; Chondrometrics GmbH, Freilassing, Germany. Electronic address:
Associations between weight change, knee subcutaneous fat and cartilage thickness in overweight and obese individuals: 4-Year data from the osteoarthritis initiative.
Osteoarthritis Cartilage
November 2023
Department of Radiology and Biomedical Imaging, University of California, San Francisco, United States.
Objective: To assess (i) the impact of changes in body weight on changes in joint-adjacent subcutaneous fat (SCF) and cartilage thickness over 4 years and (ii) the relation between changes in joint-adjacent SCF and knee cartilage thickness.
Design: Individuals from the Osteoarthritis Initiative (total=399) with > 10% weight gain (n=100) and > 10% weight loss (n=100) over 4 years were compared to a matched control cohort with less than 3% change in weight (n=199). 3.
Joint-adjacent Adipose Tissue by MRI is Associated With Prevalence and Progression of Knee Degenerative Changes: Data from the Osteoarthritis Initiative.
J Magn Reson Imaging
July 2021
Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA.
Background: Adipose tissue has recently gained interest as an independent imaging biomarker for osteoarthritis.
Purpose: To explore 1) cross-sectional associations between local subcutaneous fat (SCF) thickness at the knee and the extent of degenerative changes in overweight and obese individuals and 2) associations between local fat distribution and progression of osteoarthritis over 4 years.
Study Type: Retrospective cohort study.
Postoperative intensity-modulated radiotherapy for squamous cell carcinoma of the external auditory canal and middle ear: treatment outcomes, marginal misses, and perspective on target delineation.
Int J Radiat Oncol Biol Phys
March 2012
Division of Radiation Oncology, Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan.
Purpose: To report outcomes of the rare disease of squamous cell carcinoma (SCC) of the external auditory canal (EAC) and middle ear treated with surgery and postoperative intensity-modulated radiotherapy (IMRT). Failure patterns related to spatial dose distribution were also analyzed to provide insight into target delineation.
Methods And Materials: A retrospective review was conducted of the records of 11 consecutive patients with SCC of the EAC and middle ear who were treated with curative surgery and postoperative IMRT at one institution between January 2007 and February 2010.
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