AI Article Synopsis

  • The study investigates vascular and biliary anatomical variations in living liver donors in Pakistan, highlighting their significance for successful liver transplantation.
  • It analyzed data from 400 donors using CT scans and MRCP between March 2019 and March 2023, finding the most common anatomy to be conventional, with several variants identified.
  • The results show frequent anatomical variations in the hepatic and portal venous systems, suggesting that understanding these variations is crucial for selecting suitable donors and improving surgical outcomes in liver transplantation.

Article Abstract

Purpose: Living donor liver transplantation (LDLT) is a widely accepted option to address the lack of a deceased liver program for transplantation. Understanding vascular and biliary anatomy and their variants is crucial for successful and safe graft harvesting. Anatomic variations are common, particularly in the right hepatic lobe. To provide evidence for screening potential liver transplant donors, the presence of vascular and biliary anatomic variations in Pakistan's preoperative assessment of transplantation donor candidates was explored.

Methods: This retrospective cross-sectional study evaluated the hepatic artery, portal vein, hepatic vein, and biliary variations in living liver donors. The study included 400 living liver donors; data were collected from March 2019 to March 2023. We used a CT scan and MRCP to assess the anatomical variations.

Results: The study examined 400 liver donors aged 18 to 53 years. Conventional arterial anatomy was the most common (65.8%), followed by replaced right hepatic artery (16%) and replaced left hepatic artery (10.8%). Conventional type 1 biliary anatomy was seen in 65.8% of cases. The dominant right hepatic vein was found in 13.3% of donors. There was a significant association between the prevalence of variant portal venous anatomy with variant biliary anatomy.

Conclusion: Variations of the hepatic arterial, portal venous, and biliary systems are frequent and should be carefully evaluated while selecting a suitable living donor. A strong relationship between variant portal venous and biliary anatomy was found. These findings can aid in selecting suitable candidates and improving surgical planning for liver transplantation.

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Source
http://dx.doi.org/10.1007/s00423-023-03066-1DOI Listing

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