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Nirmatrelvir Resistance-de Novo E166V/L50V Mutations in an Immunocompromised Patient Treated With Prolonged Nirmatrelvir/Ritonavir Monotherapy Leading to Clinical and Virological Treatment Failure-a Case Report. | LitMetric
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Nirmatrelvir Resistance-de Novo E166V/L50V Mutations in an Immunocompromised Patient Treated With Prolonged Nirmatrelvir/Ritonavir Monotherapy Leading to Clinical and Virological Treatment Failure-a Case Report.

Neta S Zuckerman Efrat Bucris Danielle Keidar-Friedman Muriel Amsalem Tal Brosh-Nissimov

Clin Infect Dis

Infectious Diseases Unit, Samson Assuta Ashdod University Hospital, Ashdod, Israel.

Published: February 2024

Resistance of SARS-CoV-2 to antivirals was shown to develop in immunocompromised individuals receiving remdesivir. We describe an immunocompromised patient who was treated with repeated and prolonged courses of nirmatrelvir and developed de-novo E166V/L50F mutations in the Mpro region. These mutations were associated with clinical and virological treatment failure.

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 Source
http://dx.doi.org/10.1093/cid/ciad494DOI Listing

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