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Structural and antigenic characterization of novel and diverse glycoproteins.
bioRxiv
December 2024
Duke University, Duke Human Vaccine Institute, Durham NC 27710, USA.
(HNVs), a genus within the family, includes the highly virulent Nipah and Hendra viruses that cause yearly reoccurring outbreaks of deadly disease. Recent discoveries of several new species, including the zoonotic Langya virus, have revealed much higher antigenic diversity than currently characterized. Here, to explore the limits of structural and antigenic variation in HNVs, we construct an expanded, antigenically diverse panel of HNV fusion (F) and attachment (G) glycoproteins from 56 unique HNV strains that better reflects global HNV diversity.
View Article and Find Full Text PDFThis study reports the identification of Langya virus Korea (LayV KOR) during the surveillance of shrews in the Republic of Korea. LayV KOR represents the first identification of LayV outside of China, exhibiting approximately 80% and 95.5% homologies at nucleotide and amino acid levels.
View Article and Find Full Text PDFViruses Identified in Shrews () and Their Biomedical Significance.
Viruses
September 2024
College of Animal Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510230, China.
Article Synopsis
- * Over 190 different viruses in 32 families have been found in shrews, some of which can cause diseases in both humans and animals.
- * The review aims to provide essential information on shrews and their viruses to help raise awareness about the potential health risks they pose to public and animal health.
Isolation and characterization of IgG3 glycan-targeting antibodies with exceptional cross-reactivity for diverse viral families.
PLoS Pathog
September 2024
Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America.
Broadly reactive antibodies that target sequence-diverse antigens are of interest for vaccine design and monoclonal antibody therapeutic development because they can protect against multiple strains of a virus and provide a barrier to evolution of escape mutants. Using LIBRA-seq (linking B cell receptor to antigen specificity through sequencing) data for the B cell repertoire of an individual chronically infected with human immunodeficiency virus type 1 (HIV-1), we identified a lineage of IgG3 antibodies predicted to bind to HIV-1 Envelope (Env) and influenza A Hemagglutinin (HA). Two lineage members, antibodies 2526 and 546, were confirmed to bind to a large panel of diverse antigens, including several strains of HIV-1 Env, influenza HA, coronavirus (CoV) spike, hepatitis C virus (HCV) E protein, Nipah virus (NiV) F protein, and Langya virus (LayV) F protein.
View Article and Find Full Text PDFRecuperative potential of Indian medicinal plant compounds- a tool to encumber henipaviruses: an in -silico study.
In Silico Pharmacol
August 2024
Department of Anatomy, Sri Ramachandra Institute of Higher Education and Research (DU), Porur, Chennai, 600 116 Tamil Nadu India.
Article Synopsis
- - Henipaviruses, including Cedar, Langya, and Nipah, are highly lethal zoonotic viruses with no current treatments, prompting researchers to investigate non-toxic compounds from Indian Medicinal Plants for potential antiviral properties.
- - Out of 57 selected compounds, three—andrographolide, pterygospermin, and Salidroside—showed excellent non-toxic properties and performed well in in silico testing against henipavirus proteins.
- - Andrographolide emerged as the most promising candidate due to its strong binding potential with Cedar Virus proteins, while pterygospermin and Salidroside showed effectiveness against Langya and Nipah viruses, showcasing antiviral and additional health benefits that warrant further
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