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| http://dx.doi.org/10.1038/s41592-023-01991-z | DOI Listing |
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Imaging intracellular components in situ using super-resolution cryo-correlative light and electron microscopy.
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Department of Cell and Chemical Biology, Leiden University Medical Centre, Leiden, The Netherlands; School of Biochemistry, University of Bristol, Bristol, United Kingdom. Electronic address:
Super-resolution cryo-correlative light and electron microscopy (SRcryoCLEM) is emerging as a powerful method to enable targeted in situ structural studies of biological samples. By combining the high specificity and localization accuracy of single-molecule localization microscopy (cryoSMLM) with the high resolution of cryo-electron tomography (cryoET), this method enables accurately targeted data acquisition and the observation and identification of biomolecules within their natural cellular context. Despite its potential, the adaptation of SRcryoCLEM has been hindered by the need for specialized equipment and expertise.
View Article and Find Full Text PDFscNodes: a correlation and processing toolkit for super-resolution fluorescence and electron microscopy.
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