AI Article Synopsis
- Systemic lupus erythematosus (SLE) is a chronic autoimmune disease primarily affecting women in their childbearing years, and while pregnancy is possible with well-managed disease, there are still increased risks for complications.
- Women with SLE face higher chances of disease flare-ups and obstetric issues during pregnancy, especially if they have active disease at conception, a history of lupus nephritis, or antiphospholipid syndrome.
- To enhance pregnancy outcomes for SLE patients, it's essential to have thorough preconception counseling, adjust medications as needed, and maintain close monitoring by rheumatologists and obstetricians.
Article Abstract
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease which frequently affects women of childbearing age. Nowadays, pregnancy is not contraindicated in cases of well-controlled disease activity, but pregnancies are still at higher risk of maternal and fetal complications compared to the general population. During pregnancy and puerperium patients are at risk of disease flare, and obstetric complications are more frequent in cases of active disease at conception/beginning of pregnancy, a history of lupus nephritis, and concomitant presence of antiphospholipid syndrome. To improve pregnancy outcomes in SLE patients, appropriate preconception counseling with changes in medication, if necessary, and close rheumatological and obstetrical monitoring are fundamental. This review aims to summarize the risk factors for adverse pregnancy outcomes and provide an update on developments in medical care for pregnancy in SLE patients.
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| http://dx.doi.org/10.1016/j.berh.2023.101860 | DOI Listing |
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