AI Article Synopsis
- Nine new clerodane-type diterpenoids (caseabalanspenes A-I) were discovered from the twigs and leaves of Casearia velutina, alongside six known compounds.
- The structures of these compounds were identified using spectroscopic techniques and their molecular formulas were confirmed through high-resolution mass spectrometry.
- Among the new compounds, caseabalanspene 3 showed significant anti-inflammasome activity, reducing LDH levels in a dose-dependent manner with an IC value of 2.90 μM.
Article Abstract
Nine previously undescribed clerodane-type diterpenoids (1-9), named caseabalanspenes A-I, along with six know compounds (10-15), were isolated from the twigs and leaves of Casearia velutina. Spectroscopic data (1D and 2D NMR) analysis permitted the definition of their structures and then determination of the molecular formula of the compound by high resolution mass spectrometry (HR-ESI-MS). It is worth noting that compound 7 contains N- heterocycle. Compounds 1-8 were tested the anti-inflammasome activity, and compound 3 exhibited potent activity and decreased LDH level in a dose-dependent manner, with IC values of 2.90 μM.
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| http://dx.doi.org/10.1016/j.fitote.2023.105654 | DOI Listing |
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