A sweet way to regulate cellular growth: OGT and mTOR join forces.

Mol Cell

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

Published: August 2023

In this issue, Xu and Pan et al report a glucose-sensing and activation mechanism of mTORC1 through the glycosyltransferase OGT, which activates Raptor, allowing lysosomal targeting of mTORC1 to promote cell proliferation.

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http://dx.doi.org/10.1016/j.molcel.2023.07.016DOI Listing

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