Realistic three-layer head phantom for optically pumped magnetometer-based magnetoencephalography.

The advent of optically pumped magnetometer-based magnetoencephalography (OPM-MEG) has introduced new tools for neuroscience and clinical research. As it is still under development, the achievable performance of OPM-MEG remains to be tested, particularly in terms of source localization accuracy, which can be influenced by various factors, including software and hardware aspects. A feasible approach to comprehensively test the performance of the OPM-MEG system is to utilize a phantom that simulates the actual electrophysiological properties of the head while ensuring the precise locations of dipole sources. However, conventional water or dry phantoms can only simulate a single-sphere head model. In this work, a more realistic three-layer phantom was designed and fabricated. The proposed phantom included the scalp, skull, and cortex tissues of the head, as well as the simulated dipole sources. The scalp and cortex tissues were simulated using an electrolyte solution, while the dipole source was constructed from a coaxial cable. All main structures in the phantom were produced using 3D printing techniques, making the phantom easy to manufacture. The fabricated phantom was tested on a 36-channel OPM-MEG system, and the results showed that the dipole source inside the phantom could generate a magnetic field distribution on the scalp that was close to its theoretical values. The average source localization accuracy of 5.51 mm verified the effectiveness of the designed phantom and the performance of our OPM-MEG system. This work provides an effective test platform for OPM-MEG.